LEADER 03985nam  22007575  450 
001 9910559393403321
005 20240408144856.0
010   $a9783030940041$b(electronic bk.)
010   $z9783030940034
024 7 $a10.1007/978-3-030-94004-1
035   $a(MiAaPQ)EBC6946348
035   $a(Au-PeEL)EBL6946348
035   $a(CKB)21469055700041
035   $a(DE-He213)978-3-030-94004-1
035   $a(PPN)262167964
035   $a(EXLCZ)9921469055700041
100   $a20220405d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMacropinocytosis $eFunctions and Mechanisms /$fedited by Cosimo Commisso
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (227 pages)
225 1 $aSubcellular Biochemistry,$x2542-8810 ;$v98
300   $aIncludes index.
311 08$aPrint version: Commisso, Cosimo Macropinocytosis Cham : Springer International Publishing AG,c2022 9783030940034 
327   $aPart 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.
330   $aThis book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
410  0$aSubcellular Biochemistry,$x2542-8810 ;$v98
606   $aCytology
606   $aBiophysics
606   $aCell interaction
606   $aBiological transport
606   $aCell membranes
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aCell Biology
606   $aMechanobiological Cell Signaling
606   $aMembrane Trafficking
606   $aBiomedical Research
606   $aCitologia$2thub
608   $aLlibres electrònics$2thub
615  0$aCytology.
615  0$aBiophysics.
615  0$aCell interaction.
615  0$aBiological transport.
615  0$aCell membranes.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615 14$aCell Biology.
615 24$aMechanobiological Cell Signaling.
615 24$aMembrane Trafficking.
615 24$aBiomedical Research.
615  7$aCitologia
676   $a571.6
676   $a571.6
702   $aCommisso$b Cosimo
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910559393403321
996   $aMacropinocytosis$92832663
997   $aUNINA