LEADER 05215nam 2201501z- 450 001 9910557800303321 005 20231214133053.0 035 $a(CKB)5400000000045400 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68544 035 $a(EXLCZ)995400000000045400 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEmerging Role of Lipids in Metabolism and Disease 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (308 p.) 311 $a3-03943-701-1 311 $a3-03943-702-X 330 $aEven though initially considered as a passive means for storing energy, lipids are now regarded as multifaceted molecules with crucial structural and functional activities. For instance, some of them play essential roles as key components of cell membranes whereas others act as signaling molecules in the regulation of cell homeostasis. In recent years, lipid research has attracted increasing interest because of the involvement of this class of compounds in human health. Indeed, a plethora of pathological conditions are characterized by alterations in lipid metabolism, such as cardiovascular diseases and brain disorders. This Special Issue is a collection of papers from different experts in lipid research, with the aim of providing new insights into the physiopathological involvement of lipids and their impact on human health. This collection also demonstrates the usefulness of interdisciplinary approaches in the development of novel methods to study and manipulate lipid metabolism, which may represent an attractive target for designing effective therapeutic strategies to counteract numerous pathologies. 606 $aMedicine$2bicssc 610 $aneutral sphingomyelinase 610 $aradiation 610 $asphingomyelin metabolism 610 $apathology 610 $acell signaling 610 $abrain 610 $aadipose tissue 610 $abreast cancer 610 $aepinephrine 610 $abreast reconstruction 610 $aepicardial fat thickness 610 $avisceral fat thickness 610 $ahigh-sensitivity c-reactive protein 610 $aleptin 610 $agender 610 $afemale 610 $ahippocampus 610 $afrontal cortex 610 $aadiponectin 610 $ahaptoglobin 610 $alipocalin 610 $aBDNF 610 $asynaptic proteins 610 $aphosphatidylinositol 4,5-bisphosphate 610 $aphospholipase C 610 $acholesterol 610 $ahigh-cholesterol diet 610 $aBET proteins 610 $acell proliferation 610 $aepigenetics 610 $aHMGCR 610 $aJQ1 610 $aLDLr 610 $alipid metabolism 610 $aSREBP 610 $aTMEM97 610 $aatherosclerosis 610 $adiabetes mellitus 610 $acardiovascular disease 610 $achronic inflammation 610 $ahyperglycemia 610 $amutations 610 $alipid 610 $afatty acid 610 $aglyceride 610 $asteroid 610 $aphospholipid 610 $aoral drug absorption 610 $aprodrug 610 $aphospholipase A2 (PLA2) 610 $aacid sphingomyelinase 610 $aSOD 610 $aliver 610 $aeicosanoids 610 $aischemic stroke 610 $aischemia 610 $alipoproteins 610 $apolyunsaturated fatty acids 610 $aangiogenesis 610 $ahigh-density lipoprotein 610 $aendothelial cell 610 $ametabolism 610 $ametabolic reprogramming 610 $apulmonary fibrosis 610 $alipid mediators 610 $asphingolipids 610 $asphingosine-1-phosphate 610 $asphingosine kinase 1 610 $aprostaglandins 610 $alysophosphatidic acid 610 $aautotaxin 610 $aG-protein coupled receptors 610 $alysocardiolipin acyltransferase 610 $aphospholipase D 610 $aoxidized phospholipids 610 $aDNA damage response 610 $adouble strand breaks 610 $aATM 610 $aionizing radiation 610 $ametabolic stress 610 $aoxidative stress 610 $ap53 610 $anuclear sphingolipids 610 $alipophagy 610 $alipolysis 610 $alipid droplets 610 $alipid storage diseases 610 $alipid metabolism diseases 610 $amTORC1 610 $aTFEB 610 $aCholesterol 610 $aFatty acids 610 $aLipid mediators 610 $aLipids 610 $aLipophagy 610 $aSphingolipids 615 7$aMedicine 700 $aPallottini$b Valentina$4edt$01309613 702 $aSegatto$b Marco$4edt 702 $aPallottini$b Valentina$4oth 702 $aSegatto$b Marco$4oth 906 $aBOOK 912 $a9910557800303321 996 $aEmerging Role of Lipids in Metabolism and Disease$93029453 997 $aUNINA