LEADER 05181nam 2200901z- 450 001 9910557793603321 005 20231214133226.0 035 $a(CKB)5400000000045452 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69133 035 $a(EXLCZ)995400000000045452 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMicroelectrode Arrays and Application to Medical Devices 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (188 p.) 311 $a3-03943-174-9 311 $a3-03943-175-7 330 $aMicroelectrode arrays are increasingly used in a wide variety of situations in the medical device sector. For example, one major challenge in microfluidic devices is the manipulation of fluids and droplets effectively at such scales. Due to the laminar flow regime (i.e., low Reynolds number) in microfluidic devices, the mixing of species is also difficult, and unless an active mixing strategy is employed, passive diffusion is the only mechanism that causes the fluid to mix. For many applications, diffusion is considered too slow, and thus many active pumping and mixing strategies have been employed using electrokinetic methods, which utilize a variety of simple and complex microelectrode array structures. Microelectrodes have also been implemented in in vitro intracellular delivery platforms to conduct cell electroporation on chip, where a highly localized electric field on the scale of a single cell is generated to enhance the uptake of extracellular material. In addition, microelectrode arrays are utilized in different microfluidic biosensing modalities, where a higher sensitivity, selectivity, and limit-of-detection are desired. Carbon nanotube microelectrode arrays are used for DNA detection, multi-electrode array chips are used for drug discovery, and there has been an explosion of research into brain?machine interfaces, fueled by microfabricated electrode arrays, both planar and three-dimensional. The advantages associated with microelectrode arrays include small size, the ability to manufacture repeatedly and reliably tens to thousands of micro-electrodes on both rigid and flexible substrates, and their utility for both in vitro and in vivo applications. To realize their full potential, there is a need to develop and integrate microelectrode arrays to form useful medical device systems. As the field of microelectrode array research is wide, and touches many application areas, it is often difficult to locate a single source of relevant information. This Special Issue seeks to showcase research papers, short communications, and review articles, that focus on the application of microelectrode arrays in the medical device sector. Particular interest will be paid to innovative application areas that can improve existing medical devices, such as for neuromodulation and real world lab-on-a-chip applications. 606 $aTechnology: general issues$2bicssc 610 $aelectrothermal 610 $amicroelectrode 610 $amicrofluidics 610 $amicromixing 610 $amicropump 610 $aalternating current (AC) electrokinetics 610 $abisphenol A 610 $aself-assembly 610 $abiosensor 610 $aflexible electrode 610 $apolydimethylsiloxane (PDMS) 610 $apyramid array micro-structures 610 $alow contact impedance 610 $amultimodal laser micromachining 610 $aablation characteristics 610 $ashadow mask 610 $ainterdigitated electrodes 610 $asoft sensors 610 $aliquid metal 610 $afabrication 610 $aprinciple 610 $aarrays 610 $aapplication 610 $ainduced-charge electrokinetic phenomenon 610 $aego-dielectrophoresis 610 $amobile electrode 610 $aJanus microsphere 610 $acontinuous biomolecule collection 610 $aelectroconvection 610 $amicroelectrode array (MEA) 610 $aion beam assisted electron beam deposition (IBAD) 610 $aindium tin oxide (ITO) 610 $atitanium nitride (TiN) 610 $aneurons 610 $atransparent 610 $aislets of Langerhans 610 $ainsulin secretion 610 $aglucose stimulated insulin response 610 $aelectrochemical transduction 610 $aintracortical microelectrode arrays 610 $ashape memory polymer 610 $asoftening 610 $arobust 610 $abrain tissue oxygen 610 $ain vivo monitoring 610 $amulti-site clinical depth electrode 615 7$aTechnology: general issues 700 $aDalton$b Colin$4edt$01324161 702 $aSalari$b Alinaghi$4edt 702 $aDalton$b Colin$4oth 702 $aSalari$b Alinaghi$4oth 906 $aBOOK 912 $a9910557793603321 996 $aMicroelectrode Arrays and Application to Medical Devices$93035970 997 $aUNINA