LEADER 06180nam 2201753z- 450 001 9910557793503321 005 20231214133638.0 035 $a(CKB)5400000000045453 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68695 035 $a(EXLCZ)995400000000045453 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Psychiatry 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (288 p.) 311 $a3-03936-120-1 311 $a3-03936-121-X 330 $aThe book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders. 606 $aMedicine$2bicssc 606 $aMental health services$2bicssc 610 $acardiovascular disease 610 $acell adhesion molecules 610 $aimmunology 610 $ainflammation 610 $anervous system 610 $aschizophrenia 610 $abipolar disorder 610 $amajor depressive disorder 610 $aDNA methylation 610 $aresponse variability 610 $aantipsychotics 610 $adrug design 610 $amulti-target drugs 610 $apolypharmacology 610 $amulti-task learning 610 $amachine learning 610 $abiomarker discovery 610 $apsychiatry 610 $aserotonin 610 $a5-HT 4 receptor 610 $a5-HT4R 610 $adepression 610 $amood disorder 610 $aexpression 610 $aAlzheimer's disease 610 $acognition 610 $aParkinson's disease 610 $aforced swimming 610 $aRoman rat lines 610 $astress 610 $ahippocampus 610 $aBDNF 610 $atrkB 610 $aPSA-NCAM 610 $awestern blot 610 $aimmunohistochemistry 610 $ageneral cognitive function 610 $aintelligence 610 $aGWAS 610 $agenetic correlation 610 $achildhood-onset schizophrenia (COS) 610 $ainduced pluripotent stem cell (iPSC) 610 $acopy number variation (CNV) 610 $aearly neurodevelopment 610 $aneuronal differentiation 610 $asynapse 610 $adendritic arborization 610 $amiRNAs 610 $astress physiology 610 $acytoskeleton 610 $aactin dynamics 610 $aDRR1 610 $aTU3A 610 $aFAM107A 610 $aacid sphingomyelinase 610 $aalcohol dependence 610 $aliver enzymes 610 $asphingolipid metabolism 610 $awithdrawal 610 $aHsp90 610 $aGR 610 $astress response 610 $asteroid hormones 610 $amolecular chaperones 610 $apsychiatric disease 610 $acircadian rhythms 610 $aFKBP51 610 $aFKBP52 610 $aCyP40 610 $aPP5 610 $aDISC1 610 $aneurodevelopment 610 $aCRMP-2 610 $aproteomics 610 $aantidepressant treatment 610 $aHPA axis 610 $agene expression 610 $aFKBP5 610 $asleep 610 $asleep EEG 610 $abiomarkers 610 $aantidepressants 610 $acordance 610 $agender 610 $asex difference 610 $aantidepressant 610 $arapid-acting 610 $aKetamine 610 $aendocrinology 610 $a(2R,6R)-Hydroxynorketamine 610 $aelectroconvulsive therapy 610 $abasic-helix-loop-helix 610 $abrain 610 $acoactivator 610 $aglucocorticoids 610 $amineralocorticoid receptor knockout 610 $atranscription biology 610 $adopaminergic gene polymorphisms 610 $aaffective temperament 610 $aobesity 610 $aalpha-synuclein 610 $aSNCA 610 $amajor depression 610 $aHamilton Scale of Depression 610 $achemokines 610 $aneuroinflammation 610 $asocial defeat 610 $aImmune response 610 $aT cells 610 $asusceptibility 610 $aresilience 610 $aTreg cells 610 $aTh17 cells 610 $abehavior 610 $aPPAR? 615 7$aMedicine 615 7$aMental health services 700 $aRein$b Theo$4edt$01280404 702 $aFries$b Gabriel R$4edt 702 $aRein$b Theo$4oth 702 $aFries$b Gabriel R$4oth 906 $aBOOK 912 $a9910557793503321 996 $aMolecular Psychiatry$93016893 997 $aUNINA