LEADER 06241nam 2201777z- 450 001 9910557793503321 005 20210501 035 $a(CKB)5400000000045453 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68695 035 $a(oapen)doab68695 035 $a(EXLCZ)995400000000045453 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Psychiatry 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (288 p.) 311 08$a3-03936-120-1 311 08$a3-03936-121-X 330 $aThe book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders. 606 $aMedicine and Nursing$2bicssc 606 $aMental health services$2bicssc 610 $a(2R,6R)-Hydroxynorketamine 610 $a5-HT 4 receptor 610 $a5-HT4R 610 $aacid sphingomyelinase 610 $aactin dynamics 610 $aaffective temperament 610 $aalcohol dependence 610 $aalpha-synuclein 610 $aAlzheimer's disease 610 $aantidepressant 610 $aantidepressant treatment 610 $aantidepressants 610 $aantipsychotics 610 $abasic-helix-loop-helix 610 $aBDNF 610 $abehavior 610 $abiomarker discovery 610 $abiomarkers 610 $abipolar disorder 610 $abrain 610 $acardiovascular disease 610 $acell adhesion molecules 610 $achemokines 610 $achildhood-onset schizophrenia (COS) 610 $acircadian rhythms 610 $acoactivator 610 $acognition 610 $acopy number variation (CNV) 610 $acordance 610 $aCRMP-2 610 $aCyP40 610 $acytoskeleton 610 $adendritic arborization 610 $adepression 610 $aDISC1 610 $aDNA methylation 610 $adopaminergic gene polymorphisms 610 $aDRR1 610 $adrug design 610 $aearly neurodevelopment 610 $aelectroconvulsive therapy 610 $aendocrinology 610 $aexpression 610 $aFAM107A 610 $aFKBP5 610 $aFKBP51 610 $aFKBP52 610 $aforced swimming 610 $agender 610 $agene expression 610 $ageneral cognitive function 610 $agenetic correlation 610 $aglucocorticoids 610 $aGR 610 $aGWAS 610 $aHamilton Scale of Depression 610 $ahippocampus 610 $aHPA axis 610 $aHsp90 610 $aImmune response 610 $aimmunohistochemistry 610 $aimmunology 610 $ainduced pluripotent stem cell (iPSC) 610 $ainflammation 610 $aintelligence 610 $aKetamine 610 $aliver enzymes 610 $amachine learning 610 $amajor depression 610 $amajor depressive disorder 610 $amineralocorticoid receptor knockout 610 $amiRNAs 610 $amolecular chaperones 610 $amood disorder 610 $amulti-target drugs 610 $amulti-task learning 610 $an/a 610 $anervous system 610 $aneurodevelopment 610 $aneuroinflammation 610 $aneuronal differentiation 610 $aobesity 610 $aParkinson's disease 610 $apolypharmacology 610 $aPP5 610 $aPPAR? 610 $aproteomics 610 $aPSA-NCAM 610 $apsychiatric disease 610 $apsychiatry 610 $arapid-acting 610 $aresilience 610 $aresponse variability 610 $aRoman rat lines 610 $aschizophrenia 610 $aserotonin 610 $asex difference 610 $asleep 610 $asleep EEG 610 $aSNCA 610 $asocial defeat 610 $asphingolipid metabolism 610 $asteroid hormones 610 $astress 610 $astress physiology 610 $astress response 610 $asusceptibility 610 $asynapse 610 $aT cells 610 $aTh17 cells 610 $atranscription biology 610 $aTreg cells 610 $atrkB 610 $aTU3A 610 $awestern blot 610 $awithdrawal 615 7$aMedicine and Nursing 615 7$aMental health services 700 $aRein$b Theo$4edt$01280404 702 $aFries$b Gabriel R$4edt 702 $aRein$b Theo$4oth 702 $aFries$b Gabriel R$4oth 906 $aBOOK 912 $a9910557793503321 996 $aMolecular Psychiatry$93016893 997 $aUNINA LEADER 04463oam 2200781I 450 001 9910410651803321 005 20251017110054.0 010 $a9781000219067 010 $a1000219062 010 $a9780429189586 010 $a0429189583 010 $a9781466567573 010 $a1466567570 024 7 $a10.1201/b17442 035 $a(CKB)2670000000557260 035 $a(EBL)1613831 035 $a(SSID)ssj0001332417 035 $a(PQKBManifestationID)11795607 035 $a(PQKBTitleCode)TC0001332417 035 $a(PQKBWorkID)11376334 035 $a(PQKB)10641822 035 $a(OCoLC)891387100 035 $a(MiAaPQ)EBC1613831 035 $a(OCoLC)890089780 035 $a(ODN)ODN0004476661 035 $a(ScCtBLL)f3755df5-b65c-4e19-ba27-ad8850623fbd 035 $a(DNLM)1645945 035 $a(EXLCZ)992670000000557260 100 $a20180331h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntioxidants in sport nutrition /$fedited by Manfred Lamprecht 205 $a1st ed. 210 $d2014 210 1$aBoca Raton :$cTaylor & Francis,$d[2015] 210 4$dİ2015 215 $a1 online resource (296 p.) 300 $aDescription based upon print version of record. 311 08$a1-4665-6759-7 311 08$a1-322-63578-1 320 $aIncludes bibliographical references at the end of each chapters. 327 $aFront Cover; Contents; Preface; Editor; Contributors; Chapter 1: Mechanisms of Oxidative Damage and Their Impact on Contracting Muscle; Chapter 2: Nutritional Antioxidants : It Is Time to Categorise; Chapter 3: Antioxidants in Athlete's Basic Nutrition : Considerations towards a Guideline for the Intake of Vitamin C and Vitamin E; Chapter 4: Antioxidants in Sport Nutrition : All the Same Effectiveness?; Chapter 5: Well-Known Antioxidants and Newcomers in Sport Nutrition : Coenzyme Q10, Quercetin, Resveratrol, Pterostilbene, Pycnogenol and Astaxanthin 327 $aChapter 6: Polyphenols in Sport : Facts or Fads?Chapter 7: Supplemental Antioxidants and Adaptation to Physical Training; Chapter 8: Green Tea Catechins and Sport Performance; Chapter 9: Acute and Chronic Effects of Antioxidant Supplementation on Exercise Performance; Chapter 10: Evaluation of Quercetin as a Countermeasure to Exercise-Induced Physiological Stress; Chapter 11: Inflammation and Immune Function : Can Antioxidants Help the Endurance Athlete?; Chapter 12: Influence of Mixed Fruit and Vegetable Concentrates on Redox Homeostasis and Immune System of Exercising People 327 $aChapter 13: Methodological Considerations When Evaluating the Effectiveness of Dietary/Supplemental Antioxidants in SportChapter 14: Common Questions and Tentative Answers on How to Assess Oxidative Stress after Antioxidant Supplementation and Exercise; Chapter 15: Biomarkers Part I : Biomarkers to Estimate Bioefficacy of Dietary/Supplemental Antioxidants in Sport; Chapter 16: Biomarkers Part II : Biomarkers to Estimate Bioefficacy of Dietary/Supplemental Antioxidants in Sport; Back Cover 330 $aAntioxidant use in sports is controversial due to existing evidence that it both supports and hurts athletic performance. This book presents information on antioxidants, specifically for athletes, and their roles in sports nutrition. It stresses how antioxidants affect exercise performance, health, and immunity. Chapters cover oxidative stress; basic nutrition for athletes; major dietary antioxidants; sports supplements; performance/adaptation to exercise; antioxidants role in health and immunity; reviews on vitamins C, E, beta carotene, and minerals in sports nutrition; and roles polyphenols play in high-performance sport--$cProvided by publisher. 606 $aAntioxidants 606 $aAthletes$xNutrition 606 $aSports$xPhysiological aspects 606 $aSports medicine 615 0$aAntioxidants. 615 0$aAthletes$xNutrition. 615 0$aSports$xPhysiological aspects. 615 0$aSports medicine. 676 $a613.2/86 676 $a613.286 676 $a613.286 686 $aMED060000$aHEA017000$aMED084000$2bisacsh 700 $aLamprecht$b Manfred$01776032 702 $aLamprecht$b Manfred 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910410651803321 996 $aAntioxidants in sport nutrition$94291479 997 $aUNINA