LEADER 05319nam 2201261z- 450 001 9910557790603321 005 20231214133606.0 035 $a(CKB)5400000000045482 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76962 035 $a(EXLCZ)995400000000045482 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStaphylococcal Infections (Host and Pathogenic Factors) 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (226 p.) 311 $a3-0365-1418-X 311 $a3-0365-1417-1 330 $aAlthough 30% of the healthy human population is colonized with various Staphylococcus species, some staphylococcal strains, referred to as opportunistic pathogens, can cause minor to life-threatening diseases. The pathogenicity of these bacteria depends on their virulence factors and the robustness of the regulatory networks expressing these virulence factors. Virulence factors of pathogenic Staphylococcus spp. consist of numerous toxins, enterotoxins (some of which act as superantigens), enzymes, and proteins (cytoplasmic, extracellular, and surface) that are regulated by two-component (TC) and quorum-sensing (QS) regulatory networks. To enter this niche, some other Staphylococcus species, such as Staphylococcus simulans, produce a potent endopeptidase called lysostaphin, which can inhibit the growth of pathogenic S. aureus. Some other Staphylococcus species produce autolysins and cationic peptides to win the intra- and inter-species competition. The outcome of this microbial invasion depends not only on pathogenic factors but also on the host?s internal and external defense mechanisms, including a healthy skin microbiome. A healthy skin microbiome population can prevent colonization by other major pathogens. As normal host microflora, these commensals establish a complex relationship with the host as well as the surrounding microbial communities. This Special Issue of Microorganisms is focused on studies and recent advancements in our understanding of staphylococcal virulence mechanisms that enable Staphylococcus spp. either to successfully establish themselves as a colonizer or to overcome the host?s defense system to cause infection along with our effort to make an anti-staphylococcal vaccine. 517 $aStaphylococcal Infections 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $abiofilm 610 $aMRSA 610 $asilver ion 610 $asilver sulfadiazine 610 $awound infections 610 $aStaphylococcus aureus 610 $amethicillin resistance 610 $ahuman infection 610 $aCC130 610 $abiomaterials 610 $amedical devices 610 $aHL-60 cells 610 $aPMNs 610 $aendotracheal tube 610 $atitanium 610 $aimplantable devices 610 $anosocomial diseases 610 $aStaphylococcus lugdunensis 610 $asortase A 610 $asurface proteins 610 $aLPXTG 610 $asmall colony variants 610 $ainfluenza virus 610 $asuper-infection 610 $apro-inflammatory response 610 $arural Ghana 610 $amolecular epidemiology 610 $achronic wounds 610 $ainvasive disease 610 $asurgery-associated infection 610 $asepsis 610 $aSA4Ag vaccine 610 $aconjugated polysaccharide 610 $aClfA 610 $aMntC 610 $aprotection 610 $aanimal models 610 $aphase variation 610 $aStaphylococcus epidermidis 610 $amicrobiota 610 $amultidrug resistance 610 $agenome sequencing 610 $aphylogenetic analyses 610 $aarthroplasty surgery 610 $amethicillin-resistant Staphylococcus aureus (MRSA) 610 $acommunity-associated MRSA (CA-MRSA) 610 $aCA-MRSA strain USA300 610 $amurine skin infection model 610 $adermatopathology 610 $adermonecrosis 610 $aneutrophil 610 $ahost antibacterial response 610 $acytokine 610 $achemokine 610 $aphysiology 610 $ametabolism 610 $acarbon catabolite repression 610 $aCcpA 610 $aHPr 610 $acolonization 610 $amouse 610 $aJSNZ 610 $aaurintricarboxylic acid 610 $aATA 610 $aadhesion inhibitor 610 $amupirocin 610 $anose 610 $asuperantigen 610 $amastitis 610 $afood intoxication 610 $aregulation 610 $asec variants 610 $aCM lipids 610 $adaptomycin resistance 610 $aresensitization 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aAdhikari$b Rajan P$4edt$01297576 702 $aAdhikari$b Rajan P$4oth 906 $aBOOK 912 $a9910557790603321 996 $aStaphylococcal Infections (Host and Pathogenic Factors)$93024567 997 $aUNINA