LEADER 04876nam 2201189z- 450 001 9910557788003321 005 20231214133047.0 035 $a(CKB)5400000000045508 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68946 035 $a(EXLCZ)995400000000045508 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStem Cell Bioprocessing and Manufacturing 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (170 p.) 311 $a3-03943-038-6 311 $a3-03943-039-4 330 $aThe next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies. 606 $aMedicine$2bicssc 610 $aelectrospinning 610 $alive-cell electrospinning 610 $atissue engineering 610 $acell seeding 610 $ahigh voltage 610 $aviability 610 $aallogeneic cell therapy 610 $ainduced pluripotent stem cell 610 $ahuman embryonic stem cell 610 $acell aggregate 610 $aexpansion 610 $adifferentiation 610 $ascalable manufacturing 610 $ascale up 610 $asingle-use bioreactor 610 $aVertical-Wheel 610 $aU-shaped vessel 610 $acomputational fluid dynamics 610 $ashear stress 610 $aturbulent energy dissipation rates 610 $ahomogeneous hydrodynamic environment 610 $ahuman pluripotent stem cells 610 $ahepatic cell lineages 610 $ahepatocyte differentiation 610 $anon-parenchymal liver cells 610 $aliver organoids 610 $adisease modeling 610 $adrug screening 610 $aolfactory ensheathing cells 610 $aspinal cord injury 610 $aneural regeneration 610 $acell therapies 610 $aadipose stem cells 610 $aneurotrophic factors 610 $agrowth factors 610 $aperipheral nerve injuries 610 $afibrin nerve conduits 610 $ahydrogels 610 $astem cells delivery 610 $aaxonal regeneration 610 $aSchwann cells 610 $astromal vascular fraction 610 $astem cell 610 $aadipose-derived stem cell 610 $ainfrapatellar fat pad 610 $aknee 610 $aarthroscopy 610 $aarthrotomy 610 $abioreactor 610 $ahMSCs 610 $amicrocarrier 610 $abioprocess 610 $aembryonic stem cells 610 $amesenchymal stromal cells 610 $ablood platelets 610 $acell culture techniques 610 $aprogenitor cells 610 $ahuman adipose stem cells (hASCs) 610 $aserum- and xeno-free conditions 610 $aUrSuppe stem cell culture medium 610 $aautologous therapy 610 $akinetic growth modeling 610 $asegregated and unstructured growth model 610 $amodel predictive control 610 $abio-process 610 $acell growth 610 $alactate 610 $aadvanced therapy medicinal products 615 7$aMedicine 700 $aCabral$b Joaquim M. S$4edt$01324160 702 $aLobato da Silva$b Cla?udia$4edt 702 $aDiogo$b Maria Margarida$4edt 702 $aCabral$b Joaquim M. S$4oth 702 $aLobato da Silva$b Cla?udia$4oth 702 $aDiogo$b Maria Margarida$4oth 906 $aBOOK 912 $a9910557788003321 996 $aStem Cell Bioprocessing and Manufacturing$93035969 997 $aUNINA