LEADER 03991nam 2200973z- 450 001 9910557783503321 005 20231214133116.0 035 $a(CKB)5400000000045554 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76427 035 $a(EXLCZ)995400000000045554 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCentenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (204 p.) 311 $a3-0365-0980-1 311 $a3-0365-0981-X 330 $aPeople around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $aaging 610 $aalternative therapy 610 $acomposition of royal jelly 610 $adietary interventions 610 $ahealthspan 610 $alifespan 610 $alongevity 610 $aroyal jelly 610 $aIGF-1 610 $aoxidative stress 610 $aageing 610 $anematode 610 $aimmunosenescence 610 $aprobiotic bacteria 610 $apathogen protection 610 $afood allergy 610 $aelderly 610 $ahypersensitivity 610 $agut 610 $aallergy 610 $ainflammation 610 $aredoxomics 610 $aglutathione 610 $ameniere's disease 610 $aneurodegenerative diseases 610 $ahealthy aging 610 $aDNA methylation 610 $aepigenetic clocks 610 $atelomere length 610 $acentenarians 610 $aexosomes 610 $aserum 610 $afunctional enrichment analysis 610 $aingenuity pathway analysis 610 $amiRNA-mRNA networks 610 $aaging-related disease 610 $aDi (2-Ethylhexyl) pthalate 610 $aHericium erinaceus 610 $avitagenes 610 $aapoptosis 610 $amitochondrial respiratory complexes 610 $aC. elegans 610 $apolyphenols 610 $aolive oil 610 $aParkinson's disease 610 $a?-Dystroglycan 610 $acellular senescence 610 $alamin B1 610 $aDNA-damage response 610 $adefective mitosis 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aPuca$b Annibale$4edt$01328819 702 $aCaruso$b Calogero$4edt 702 $aPuca$b Annibale$4oth 702 $aCaruso$b Calogero$4oth 906 $aBOOK 912 $a9910557783503321 996 $aCentenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan$93645513 997 $aUNINA