LEADER 03201nam 2200601z- 450 001 9910557770303321 005 20231214132953.0 035 $a(CKB)5400000000045658 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68400 035 $a(EXLCZ)995400000000045658 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEutectic Solvents 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (126 p.) 311 $a3-0365-0022-7 311 $a3-0365-0023-5 330 $aNatural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin?NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption. 606 $aResearch & information: general$2bicssc 610 $adeep eutectic solvents 610 $amolecularly imprinted polymers 610 $aextraction 610 $aphenolic compounds 610 $aantioxidant activity 610 $aspruce bark 610 $aphytomass 610 $avalorization 610 $adeep eutectic solvent 610 $acomposite resins 610 $ahydrogen bond 610 $aeutectic solvents 610 $anatural deep eutectic solvents 610 $ananostructured ionic solvents 610 $aneoteric solvents 610 $aionic liquids 610 $aionic liquid 610 $ahybrid solvent 610 $aCO2 solubility 610 $aHenry?s constant 610 $aviscosity 615 7$aResearch & information: general 700 $aCysewski$b Piotr$4edt$01297574 702 $aJeli?ski$b Tomasz$4edt 702 $aCysewski$b Piotr$4oth 702 $aJeli?ski$b Tomasz$4oth 906 $aBOOK 912 $a9910557770303321 996 $aEutectic Solvents$93024565 997 $aUNINA