LEADER 05874nam 2201453z- 450 001 9910557761103321 005 20220111 035 $a(CKB)5400000000045751 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76512 035 $a(oapen)doab76512 035 $a(EXLCZ)995400000000045751 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (286 p.) 311 08$a3-0365-0256-4 311 08$a3-0365-0257-2 330 $aThis book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor. 517 $aCytochromes P450 606 $aResearch and information: general$2bicssc 610 $a20-HETE 610 $aactive site access channels 610 $aAntibiotics 610 $aarachidonic acid 610 $aazole drugs 610 $aBacillus 610 $aBietti's crystalline dystrophy 610 $abiosynthetic gene clusters 610 $acavities boundaries 610 $acirculatory CYPs 610 $acomparative analysis 610 $acryptococcus 610 $acryptococcus neoformans 610 $acrystal structure 610 $aCyanobacteria 610 $aCYP diversity analysis 610 $aCYP128A1 610 $aCYP139A1 610 $aCYP2C8 610 $aCYP3A4 610 $aCYP4 genes 610 $aCYP450 610 $aCYP51 610 $aCytochrome b5 (CYB5) 610 $acytochrome P450 610 $acytochrome P450 monooxygenase 610 $acytochrome P450 monooxygenases 610 $acytochrome P450 monooxygenenases 610 $acytochrome P450 reductase 610 $acytochromes P450 610 $acytochromes P450 monooxygenases 610 $adrug metabolism 610 $aelectron transfer 610 $aelectron-transfer (ET) 610 $aenzyme substrate specificity 610 $aexosomes 610 $aextracellular vesicles 610 $aextrahepatic tissues 610 $afatty acid 610 $afungal pathogens 610 $agene-cluster diversity percentage 610 $agenetic polymorphisms 610 $agenome data mining 610 $agenome data-mining 610 $ahost metabolism 610 $ahuman pathogens 610 $aisoform 610 $alamellar ichthyosis 610 $amathematical formula 610 $amechanism-based inhibitor 610 $amembrane protein 610 $amenaquinone 610 $ametabolism 610 $amicrosomal cytochrome P450 (CYP) 610 $aminimal cost paths 610 $amolecular dynamic simulations 610 $amolecular dynamics simulation 610 $amolecular functionality 610 $amutagenesis 610 $aMycobacterium 610 $aMycobacterium tuberculosis 610 $aMycobacterium tuberculosis H37Rv 610 $aNADPH-cytochrome P450 reductase (CPR) 610 $anon-ribosomal peptides 610 $aP450 blooming 610 $aP450 diversity percentage 610 $aP450 profiling 610 $apaclitaxel 610 $aphylogenetic analysis 610 $aplasma 610 $apolyketides 610 $apolymorphisms 610 $aprecision Cardio-Oncology 610 $aprecision medicine 610 $aprotein dynamics 610 $aprotein-membrane interactions 610 $aprotein-protein interaction 610 $areactive oxygen species 610 $aRNA interference 610 $asecondary metabolites 610 $aSNPs 610 $aSogatella furcifera 610 $aStreptomyces 610 $asulfoxaflor 610 $asystems medicine 610 $aterpenes 610 $atranscriptome 610 $atremellomycetes 610 $atrichosporon 610 $atuberculosis 615 7$aResearch and information: general 700 $aDansette$b Patrick M$4edt$01319364 702 $aWerck$b Daničle$4edt 702 $aDansette$b Patrick M$4oth 702 $aWerck$b Daničle$4oth 906 $aBOOK 912 $a9910557761103321 996 $aCytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0$93033829 997 $aUNINA