LEADER 04391nam 2201141z- 450 001 9910557760203321 005 20231214133044.0 035 $a(CKB)5400000000045760 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68274 035 $a(EXLCZ)995400000000045760 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOligodendrocyte Physiology and Pathology Function 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (330 p.) 311 $a3-03943-689-9 311 $a3-03943-690-2 330 $aThe adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte?axon?myelin unit. 606 $aMedicine$2bicssc 606 $aNeurosciences$2bicssc 610 $aplasma membrane proteins 610 $aliquid chromatography-mass spectrometry 610 $amurine acute brain slices 610 $areproducibility 610 $arat cerebellum 610 $aNsun5 610 $aWilliams-Beuren syndrome (WBS) 610 $acorpus callosum (CC) 610 $aoligodendrocyte (OL) 610 $amyelination 610 $aremyelination 610 $aEGFR inhibitor 610 $asmoothened agonist 610 $amicrofibers 610 $adrug screening 610 $amultiple sclerosis 610 $acuprizone 610 $aatrophy 610 $adesign-based stereology 610 $a18F-FDG 610 $amacromolecular proton fraction 610 $aMPF 610 $amyelin 610 $amagnetic resonance imaging 610 $acuprizone model 610 $ademyelination 610 $aoligodendrocyte precursors 610 $aoligodendrocytes 610 $aimmunohistochemistry 610 $aoligodendrocyte 610 $aepigenetics 610 $aneurodegeneration 610 $alaquinimod 610 $aenergy drinks 610 $acaffeine 610 $ataurine 610 $aneuron 610 $aOPC 610 $aoligodendrocyte progenitor cells 610 $ascreening 610 $ananofibers 610 $aDigiGait? 610 $aexperimental autoimmune encephalomyelitis 610 $agait analysis 610 $aschizophrenia 610 $ainterneuron 610 $apluripotent stem cells 610 $acognition 610 $atreatment 610 $acre-recombinase 610 $aexperimental autoimmune encephalomyelitis (EAE) 610 $aglial progenitor cells 610 $atamoxifen 610 $adown syndrome 610 $awhite matter 610 $aglial fate 610 $atransient receptor potential ankyrin 1 610 $aastrocyte 610 $aconditional knockout 610 $aastrocytes 610 $awhite matter disease 610 $across-talk 610 $aCNS 610 $aglial cells. 610 $aage 610 $amicroglia 615 7$aMedicine 615 7$aNeurosciences 700 $aKipp$b Markus$4edt$01324155 702 $aKipp$b Markus$4oth 906 $aBOOK 912 $a9910557760203321 996 $aOligodendrocyte Physiology and Pathology Function$93035962 997 $aUNINA