LEADER 03932nam 2200817z- 450 001 9910557757603321 005 20240923225533.0 035 $a(CKB)5400000000045786 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76954 035 $a(EXLCZ)995400000000045786 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMitochondria: From Physiology to Pathology 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (196 p.) 311 $a3-0365-2151-8 311 $a3-0365-2152-6 330 $aMitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ?hubs? are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ?Mitochondria: from Physiology to Pathology? published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. 517 $aMitochondria 606 $aResearch & information: general$2bicssc 610 $aatherosclerosis 610 $acarotid intima-media thickness 610 $amitochondrial mutations 610 $acardiovascular risk factors 610 $amitochondria 610 $amtDNA 610 $acristae 610 $amitochondrial fission 610 $amitochondrial fusion 610 $amitochondrial disease 610 $amitochondrial dynamics 610 $amitoenergetics 610 $amitosteroidogenesis 610 $aLH 610 $acAMP 610 $aLeydig cell 610 $amitochondrial DNA segregation 610 $aheteroplasmy 610 $aselective elimination 610 $amitophagy 610 $amitochondrial engineered nucleases 610 $akinases 610 $aphosphorylation 610 $adisease 610 $aPINK1 610 $aParkinson's disease 610 $amitochondria homeostasis 610 $aCterm 610 $aMELAS 610 $atransmitochondrial cybrids 610 $aaminoacyl-tRNA synthetases 610 $aLARS2 610 $amitochondrial disease 610 $atherapeutic peptides 610 $aFAD synthase 610 $aFAD1 610 $amitochondria localization 610 $aSaccharomyces cerevisiae 610 $amRNA 610 $amitochondrial localization motif 615 7$aResearch & information: general 700 $aBruni$b Francesco$4edt$068736 702 $aBruni$b Francesco$4oth 906 $aBOOK 912 $a9910557757603321 996 $aMitochondria: From Physiology to Pathology$93024372 997 $aUNINA