LEADER 02643nam 2200421z- 450 001 9910220041203321 005 20210211 035 $a(CKB)3800000000216365 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49645 035 $a(oapen)doab49645 035 $a(EXLCZ)993800000000216365 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aHuman Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins 210 $cFrontiers Media SA$d2016 215 $a1 online resource (97 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-961-4 330 $aTP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation. 517 $aHuman Tumor-Derived p53 Mutants 606 $aMedicine$2bicssc 610 $adominant netagive 610 $again of function 610 $amouse models 610 $amutant p53 610 $aOncogenic addiction 610 $atherapies 615 7$aMedicine 700 $aGiovanni Blandino$4auth$044946 702 $aYgal Haupt$4auth 906 $aBOOK 912 $a9910220041203321 996 $aHuman Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins$93040071 997 $aUNINA LEADER 03917nam 2200877z- 450 001 9910557754503321 005 20210501 035 $a(CKB)5400000000045817 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69286 035 $a(oapen)doab69286 035 $a(EXLCZ)995400000000045817 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aImpacts of Landscape Change on Water Resources 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (180 p.) 311 08$a3-03943-426-8 311 08$a3-03943-427-6 330 $aChanges in land use and land cover can have many drivers, including population growth, urbanization, agriculture, demand for food, evolution of socio-economic structure, policy regulations, and climate variability. The impacts of these changes on water resources range from changes in water availability (due to changes in losses of water to evapotranspiration and recharge) to degradation of water quality (increased erosion, salinity, chemical loadings, and pathogens). The impacts are manifested through complex hydro-bio-geo-climate characteristics, which underscore the need for integrated scientific approaches to understand the impacts of landscape change on water resources. Several techniques, such as field studies, long-term monitoring, remote sensing technologies, and advanced modeling studies, have contributed to better understanding the modes and mechanisms by which landscape changes impact water resources. Such research studies can help unlock the complex interconnected influences of landscape on water resources in terms of quantity and quality at multiple spatial and temporal scales. In this Special Issue, we published a set of eight peer-reviewed articles elaborating on some of the specific topics of landscape changes and associated impacts on water resources. 606 $aHistory of engineering and technology$2bicssc 610 $abank erosion 610 $abest management practices (BMPs) 610 $adiversity 610 $aDMMF 610 $adrip irrigation 610 $aEthiopia 610 $aevapotranspiration 610 $aflood analysis 610 $aflood zone delineation 610 $agroundwater potential 610 $aHEC-RAS 610 $ahydrodynamic modeling 610 $ahydrologic modeling 610 $ahydrologic response units (HRUs) 610 $ahydrologically connected fields 610 $ahydrology 610 $aimpact assessment 610 $aimpervious area 610 $alandscape change 610 $alandscape configuration 610 $alandscape ecology 610 $alandscape metrics 610 $alandscape scale 610 $aLID practices 610 $aMarys River watershed 610 $apeak flow 610 $aSajo? River 610 $ascaling-up conservation agriculture 610 $ashallow subsurface runoff and infiltration 610 $aslope positions 610 $asoil temperature 610 $asolar energy 610 $aspatial configuration units 610 $aspatial optimization 610 $astream temperature 610 $asurface runoff 610 $asustainable intensification 610 $aSWAT 610 $aUAV 610 $aVELMA 610 $awater modeling 610 $awater resources analysis 610 $awatershed model 610 $awatershed process simulation 610 $awatershed scale 615 7$aHistory of engineering and technology 700 $aJha$b Manoj K$4edt$01328372 702 $aJha$b Manoj K$4oth 906 $aBOOK 912 $a9910557754503321 996 $aImpacts of Landscape Change on Water Resources$93038545 997 $aUNINA