LEADER 05821nam 2201633z- 450 001 9910557746603321 005 20210501 035 $a(CKB)5400000000045876 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69041 035 $a(oapen)doab69041 035 $a(EXLCZ)995400000000045876 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMicrobial Virulence Factors 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (400 p.) 311 08$a3-03936-946-6 311 08$a3-03936-947-4 330 $aMicrobial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic. 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $a5637 bladder cells 610 $aactin 610 $aactin proteolysis 610 $aActinomycetales 610 $aAeromonas hydrophila 610 $aanti-virulence 610 $aantibiotic resistance 610 $aantimicrobial peptide 610 $aantimicrobial peptides 610 $aapple 610 $aapple proliferation 610 $aautotransporter 610 $abacteria 610 $abacterial invasion 610 $abacterial pathogens 610 $abacterial surface protein 610 $abiofilm 610 $abiofilm formation 610 $ablood-brain barrier 610 $ablood-cerebrospinal fluid barrier 610 $aBordetella pertussis 610 $aBurkholderia cepacia complex 610 $aCandida 610 $aCandida albicans 610 $achronic infection 610 $aCitrobacter 610 $acoagulase-negative staphylococci 610 $acomplement 610 $acompound appressorium 610 $acovalent labeling 610 $acystic fibrosis 610 $acytotoxicity 610 $aDickeya solani 610 $adifferential expression proteins 610 $aEDTA 610 $aeffector protein 610 $aEnterobacter 610 $aEnterobacterales 610 $afluconazole 610 $afungal pathogens 610 $afungicidal activity 610 $agelatin 610 $agene expression 610 $aglobal regulator 610 $agrimelysin 610 $aHfq 610 $ahost-pathogen interaction 610 $ahyphae 610 $aimmune evasion 610 $aimmune response 610 $ainfection 610 $ainflammation 610 $ainter-kingdom protection 610 $ainterspecies interactions 610 $aintracellular survival 610 $aKlebsiella 610 $alon expression 610 $aLysR-family 610 $amanipulation 610 $ameningitis 610 $ametalloproteinases 610 $amicrobial virulence factors 610 $amorphology 610 $amotility 610 $amucin 610 $aomics analysis 610 $aouter membrane vesicles (OMVs) 610 $aoxidative stress 610 $apathogenicity 610 $apathogenomics 610 $apectinolytic enzymes 610 $apersistence 610 $aphytoplasma 610 $aplant pathogen 610 $aprimary ciliary dyskinesia 610 $aprotealysin 610 $aprotease ECP 32 610 $aprotease Lon 610 $aproteomics analysis 610 $aPseudomonas aeruginosa 610 $apyolysin 610 $areplicative niche 610 $aresistance to stress 610 $aSalmonella enterica serovar Typhimurium 610 $aSclerotinia sclerotiorum 610 $aserine proteases 610 $aserum resistance 610 $asmall noncoding regulatory RNAs 610 $asolute-binding proteins 610 $aSPATEs 610 $asputum 610 $aSpyCatcher 610 $aSsNsd1 610 $aT3SS 610 $atopology mapping 610 $atruA 610 $aTrueperella pyogenes 610 $atwo-dimensional electrophoresis 610 $atype III secretion system 610 $ausg 610 $aUTIs 610 $avirulence 610 $avirulence factor 610 $avirulence factors 610 $awhole genome sequencing 610 $a?lahS 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aLeitão$b Jorge H$4edt$01326281 702 $aLeitão$b Jorge H$4oth 906 $aBOOK 912 $a9910557746603321 996 $aMicrobial Virulence Factors$93037260 997 $aUNINA