LEADER 01184nam2-2200397---450- 001 990002145230203316 005 20100202122240.0 010 $a978-1-60761-197-4 010 $a978-1-60761-198-1$b(online) 035 $a000214523 035 $aUSA01000214523 035 $a(ALEPH)000214523USA01 035 $a000214523 100 $a20041105d2009----km-y0itay50------ba 101 0 $aeng 102 $aUS 105 $aa|||||||001yy 200 1 $aChemotaxis$emethods and protocols$fedited by Tian Jin and Dale Hereld 210 $aNew York$cHumana Press$d2009 215 $aXV, 537 p.$cill.$d27 cm 225 2 $aMethods in molecular biology$v571 410 0$1001000336582$12001$aMethods in molecular biology$v, 571 606 0 $aChemiotassi 676 $a571.67 702 1$aJIN,$bTian 702 1$aHERELD,$bDale 801 0$aIT$bsalbc$gISBD 912 $a990002145230203316 951 $a571.67 CHE$b5310 Farm.$c571.67$d00255475 959 $aBK 969 $aFAR 979 $aMARIA$b10$c20041105$lUSA01$h1302 979 $aANNAMARIA$b90$c20100202$lUSA01$h1144 979 $aANNAMARIA$b90$c20100202$lUSA01$h1222 996 $aChemotaxis$91038935 997 $aUNISA LEADER 03583oam 2200481z 450 001 9910479930303321 005 20211104155902.0 010 $a9781988531410$b(electronic bk.) 010 $a1988531411$b(electronic bk.) 010 $a9781988531403$b(electronic bk.) 010 $a1988531403$b(electronic bk.) 035 $a(CKB)4100000007591217 035 $a(MiAaPQ)EBC5651791 035 $a(EXLCZ)994100000007591217 100 $a20190630d2018 uy 0 101 0 $aeng 135 $aurcnu---unuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFlu hunter $eunlocking the secrets of a virus /$fRobert G. Webster 210 1$aDunedin, New Zealand :$cOtago University Press,$d2018. 215 $a1 online resource $cillustrations (some color), color maps 311 08$aPrint version: Webster, Robert G., 1932- Flu hunber. Dunedin, New Zealand : Otago University Press, 2018 1988531314 320 $aIncludes bibliographical references and index. 327 $aForeword / by Lance Jennings -- Emergence of the monster: Spanish influenza, 1918 -- The start of influenza research -- From seabirds in Australlia to Tamiflu -- The search moves to wild ducks in Canada -- Delaware Bay: the right place at the right time -- Proving interspecies transmission -- Virologists visit China -- Hong Kong hotbed: live bird markets and pig processing -- Searching the world, 1975-95 -- The smoking gun -- Bird flu: the rise and spread of H5N1 -- The first pandemic of the 21st century -- SARS, and a second bird flu outbreak -- Digging for answers on the 1918 Spanish influenza -- Resurrecting the 1918 Spanish influenza -- Opening Pandora's Box -- Looking to the future: are we better prepared. 330 $a"When a new influenza virus emerges that is able to be transmitted between humans, it spreads globally as a pandemic, often with high mortality. Enormous social disruption and substantial economic cost can result. The 1918 Spanish influenza pandemic was undoubtedly the most devastating influenza pandemic to date, and it has been Dr Robert Webster's life's work to figure out how and why. In so doing he has made a remarkable contribution to our understanding of the evolution of influenza viruses and how to control them. A century on, Flu Hunter is a gripping account of the tenacious scientific detective work involved in revealing the secrets of this killer virus. Dubbed `Flu Hunter' by Smithsonian Magazine in 2006, Dr Webster began his research in the early 1960s with the insight that the natural ecology of most influenza viruses is among wild aquatic birds. Painstaking tracking and testing of thousands of birds eventually led him and the other scientists involved to establish a link between these bird virus `reservoirs' and human influenza pandemics. Some of this fascinating scientific work involved exhuming bodies of Spanish flu victims from the Arctic permafrost in a search for tissue samples containing genetic material from the virus" --Publisher. 606 $aInfluenza$xHistory$y20th century 606 $aEpidemics$xHistory$y20th century 606 $aAvian influenza 606 $aDisasters 606 $aInfluenza$xEpidemiology 615 0$aInfluenza$xHistory 615 0$aEpidemics$xHistory 615 0$aAvian influenza. 615 0$aDisasters. 615 0$aInfluenza$xEpidemiology. 676 $a616.203019 700 $aWebster$b Robert G.$f1932-$0850555 906 $aBOOK 912 $a9910479930303321 996 $aFlu hunter$91899104 997 $aUNINA LEADER 04181nam 2201129z- 450 001 9910557741603321 005 20210501 035 $a(CKB)5400000000045926 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68974 035 $a(oapen)doab68974 035 $a(EXLCZ)995400000000045926 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRole of Genomics in the Management of Hypertension 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (200 p.) 311 08$a3-03936-627-0 311 08$a3-03936-628-9 330 $aArterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field. 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $aadducin 610 $aAfrican American 610 $aaldosterone 610 $aaldosterone-producing adenoma 610 $aARMC5 610 $aatrial natriuretic peptide 610 $ablood pressure 610 $aburden test 610 $aCACNA1D 610 $acardiac hypertrophy 610 $acardio-tonic steroids 610 $acardiovascular diseases 610 $acervical artery dissection 610 $aCRY1 610 $aCRY2 610 $aDNA methylation 610 $aendocrine hypertension 610 $aendogenous ouabain 610 $aendothelial cells 610 $aendothelial dysfunction 610 $aepigenetics 610 $aessential hypertension 610 $aexome microarray 610 $afibromuscular dysplasia 610 $agenetic association 610 $agenetics 610 $agenetics of left ventricular hypertrophy 610 $agenome-wide association studies 610 $aGRK4 610 $aheart failure 610 $ahistone modifications 610 $aHSD3B1 610 $aHSD3B2 610 $ahypertension 610 $ahypokalemia 610 $aKruppel-like factor 15 610 $aleft ventricular hypertrophy 610 $aLiddle syndrome 610 $alow renin hypertension 610 $alow-renin 610 $amicro RNA 610 $amineralocorticoid receptor 610 $amonogenic hypertension 610 $anext-generation sequencing 610 $anon atherosclerotic vascular stenosis 610 $anon-coding RNA 610 $aPHACTR1 610 $aplatelet aggregation 610 $aprimary aldosteronism 610 $arare variants 610 $arare-variants association testing 610 $arenal damage 610 $arenin 610 $aSCNN1A 610 $aSCNN1B 610 $aSCNN1G 610 $asequence kernel association test 610 $asmooth muscle cells contraction 610 $aspontaneous coronary arteries dissection 610 $aT2238C variant 610 $atranscriptome profiing 610 $avascular smooth muscle cells 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aMulatero$b Paolo$4edt$01329482 702 $aMonticone$b Silvia$4edt 702 $aMulatero$b Paolo$4oth 702 $aMonticone$b Silvia$4oth 906 $aBOOK 912 $a9910557741603321 996 $aRole of Genomics in the Management of Hypertension$93039499 997 $aUNINA