LEADER 01092nam a2200265 i 4500 001 991004054419707536 008 081121s2008 it 000 0 ita d 020 $a9788843045747 035 $ab13792593-39ule_inst 040 $aDip.to Filologia Class. e Scienze Filosofiche$bita 082 0 $a613.262 082 0 $a179.3 100 1 $aMannucci, Erica Joy $0262110 245 13$aLa cena di Pitagora :$bstoria del vegetarianismo dall'antica Grecia a Internet /$cErica Joy Mannucci 260 $aRoma :$bCarocci,$c2008 300 $a156 p. ;$c22 cm 440 0$aQuality paperbacks ;$v246 650 4$aVegetarianismo$xConcezione$xStoria 907 $a.b13792593$b11-03-09$c21-11-08 912 $a991004054419707536 945 $aLE007 179 MAN 01.01$g1$i2007000167328$lle007$nLE007 2008 Giannini$op$pE13.50$q-$rl$s- $t0$u1$v0$w1$x0$y.i14891219$z27-11-08 945 $aLE007 179 MAN 01.01 $g2$i2007000179437$lle007$op$pE13.50$q-$rl$s- $t0$u0$v0$w0$x0$y.i14942094$z11-03-09 996 $aCena di Pitagora$91016513 997 $aUNISALENTO 998 $ale007$b21-11-08$cm$da $e-$fita$git $h3$i0 LEADER 05693nam 2200961z- 450 001 9910557725303321 005 20220111 035 $a(CKB)5400000000046071 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76548 035 $a(oapen)doab76548 035 $a(EXLCZ)995400000000046071 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEmbryoGenetics 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (176 p.) 311 08$a3-0365-1152-0 311 08$a3-0365-1153-9 330 $aThe science of human genetics has advanced at an exponential pace since the double-helix structure of DNA was identified in 1953. Within only 25 years of that discovery, the first gene was sequenced. Subsequent efforts in the span of a few decades have brought advanced next-generation sequencing and new tools for genome editing, allowing scientists to write and rewrite the code of life. We are now realizing that genetics represents yet another system of information technology that follows Moore's law, stating that computer processing power roughly doubles every two years. Importantly, with such rapid and sophisticated advancements, any tools or studies applicable to adult genetics can now also be applied to embryos.Genetic disorders affect 1% of live births and are responsible for 20% of pediatric hospitalizations and 20% of infant mortality. Many disorders are caused by recessive or X-linked genetic mutations carried by 85% of humans. Because assisted reproduction has armed us with technologies like in vitro fertilization that provide access to human embryos, we began to screen some genetic diseases simply by selecting sex. The first live births following preimplantation genetic testing (PGT) to identify sex in X-linked disease were reported by Alan Handyside in 1990. This groundbreaking work used the identification of male embryos and selective transfer of unaffected normal or carrier females as proof-of-concept to avoid genetic diseases, paving the way to extend the concept to PGT for monogenic diseases (PGT-M), including Mendelian single-gene defects (autosomal dominant/recessive, X-linked dominant/recessive), severe childhood lethality or early-onset disease, cancer predisposition, and HLA typing for histocompatible cord-blood stem cells' transplantation. Later, we moved onto the identification and selection of euploid embryos by analysing all 23 pairs of chromosomes in 4-8 cells from the trophectoderm, called PGT for aneuploidy (PGT-A). PGT-A currently leverages next-generation sequencing technologies to uncover meiotic- and mitotic-origin aneuploidies affecting whole chromosomes, as well as duplications/deletions of small chromosome regions. A step forward was the use of structural chromosome rearrangements (PGT-SR) to identify Robertsonian and reciprocal translocations, inversions, and balanced vs. unbalanced rearrangements. Another advancement came with PGT for polygenic risk scoring (PGT-P). This technique takes us from learning how to read simple words to starting to understand poetry (i.e., evolving from PGT-M/A/SR to PGT-P for multifactorial, polygenic risk prediction). Moreover, we are moving from embryo selection to intervention because the genetic code is not only readable, but also re-writeable. Indeed, gene editing is now possible using tools like CRISPR/Cas9, which are applicable to all species, including human embryos. 606 $aResearch and information: general$2bicssc 610 $aadvanced maternal age 610 $aaneuploidies 610 $aaneuploidy 610 $aapoptotic bodies 610 $aAutosomal dominant polycystic kidney disease (ADPKD) 610 $ablastocyst 610 $achromosomal abnormality 610 $acombined preimplantation genetic testing 610 $aDNA 610 $aembryo 610 $aembryo genetics 610 $aembryos 610 $aendometrium 610 $aexosomes 610 $aextracellular vesicles 610 $afemale age 610 $agenetic diseases 610 $agenetic testing 610 $agenome editing 610 $agenomic index 610 $aimplantation 610 $ainfertility 610 $amale infertility 610 $amicrovesicles 610 $amonogenic disease 610 $amosaicism 610 $amultiplex PCR 610 $amurine blastocysts 610 $anext-generation sequencing 610 $aNGS 610 $aovarian response 610 $aperinatal care 610 $aPGT-A 610 $aPGT-P 610 $aPGT-SR 610 $apolygenic disease 610 $apolygenic risk scoring 610 $apreimplantation embryos 610 $apreimplantation genetic testing 610 $aPreimplantation genetic testing for aneuploidy assessment (PGT-A) 610 $aPreimplantation genetic testing for monogenic disorders (PGT-M) 610 $arelative risk reduction 610 $areproductive health 610 $asegmental 610 $aSNP array 610 $atranslocations 610 $auterus 610 $avitrification 610 $awhole exome sequencing 610 $awindow of implantation 615 7$aResearch and information: general 700 $aSimón$b Carlos$4edt$01242032 702 $aRubio$b Carmen$4edt 702 $aSimón$b Carlos$4oth 702 $aRubio$b Carmen$4oth 906 $aBOOK 912 $a9910557725303321 996 $aEmbryoGenetics$93040900 997 $aUNINA