LEADER 00945nam a2200253 i 4500 001 991000481069707536 005 20020506130954.0 008 010315s1963 it ||| | ita 035 $ab10706690-39ule_inst 035 $aEXGIL146441$9ExL 040 $aBiblioteca Interfacoltà$bita 082 0 $a872.01 100 1 $aBrugnoli, Giorgio$0182653 245 10$aUt patet per Seneca in suis tragediis /$cGiorgio Brugnoli 260 $aRoma :$bEdizioni dell'Ateneo,$c1963 300 $a54 p. 500 $aEstr. da: Rivista di cultura classica e medievali, a. 5, n.1 (1963) 650 4$aSeneca, Lucio Anneo - Tragedie 907 $a.b10706690$b02-04-14$c28-06-02 912 $a991000481069707536 945 $aLE002 Busta 47 9$g1$i2002000757876$lle002$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i10802307$z28-06-02 996 $aUt patet per Seneca in suis tragediis$9909129 997 $aUNISALENTO 998 $ale002$b01-01-01$cm$da $e-$fita$git $h0$i1 LEADER 02328nam 2200469z- 450 001 9910557717603321 005 20211118 035 $a(CKB)5400000000046149 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73719 035 $a(oapen)doab73719 035 $a(EXLCZ)995400000000046149 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aShankopathies: Shank Protein Deficiency-Induced Synaptic Diseases 210 $cFrontiers Media SA$d2020 215 $a1 online resource (231 p.) 311 08$a2-88963-567-8 330 $aShank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons. 517 $aShankopathies 606 $aNeurosciences$2bicssc 606 $aScience: general issues$2bicssc 610 $abrain regions 610 $amodulating factors 610 $aneuropsychiatric disorders 610 $aShank 610 $aShankopathies 615 7$aNeurosciences 615 7$aScience: general issues 700 $aEy$b Elodie$4edt$01330027 702 $aBourgeron$b Thomas$4edt 702 $aBoeckers$b Tobias M$4edt 702 $aKim$b Eunjoon$4edt 702 $aHan$b Kihoon$4edt 702 $aEy$b Elodie$4oth 906 $aBOOK 912 $a9910557717603321 996 $aShankopathies: Shank Protein Deficiency-Induced Synaptic Diseases$93039702 997 $aUNINA