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035   $a(CKB)5400000000046149
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73719
035   $a(EXLCZ)995400000000046149
100   $a20202111d2020      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aShankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
210   $cFrontiers Media SA$d2020
215   $a1 electronic resource (231 p.)
311   $a2-88963-567-8 
330   $aShank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.
517   $aShankopathies
606   $aScience: general issues$2bicssc
606   $aNeurosciences$2bicssc
610   $aShank
610   $aShankopathies
610   $aneuropsychiatric disorders
610   $amodulating factors
610   $abrain regions
615  7$aScience: general issues
615  7$aNeurosciences
700   $aEy$b Elodie$4edt$01330027
702   $aBourgeron$b Thomas$4edt
702   $aBoeckers$b Tobias M$4edt
702   $aKim$b Eunjoon$4edt
702   $aHan$b Kihoon$4edt
702   $aEy$b Elodie$4oth
906   $aBOOK
912   $a9910557717603321
996   $aShankopathies: Shank Protein Deficiency-Induced Synaptic Diseases$93039702
997   $aUNINA