LEADER 04402nam  2201333z- 450 
001 9910557717203321
005 20231214133037.0
035   $a(CKB)5400000000046153
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68994
035   $a(EXLCZ)995400000000046153
100   $a20202105d2020      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMatrix Metalloproteinase
210   $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020
215   $a1 electronic resource (262 p.)
311   $a3-03936-648-3 
311   $a3-03936-649-1 
330   $aZinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.
606   $aResearch & information: general$2bicssc
606   $aBiology, life sciences$2bicssc
610   $ahemagglutinin-B
610   $atranswell co-cultures
610   $amatrix metalloproteinases
610   $aTNF-?
610   $amatrix metalloproteinase
610   $aperitoneal mesothelial cell
610   $agastric cancer
610   $ametastatic dissemination
610   $aMT4-MMP
610   $acancer
610   $adiseases
610   $aaggrecan
610   $aaggrecanase
610   $aADAMTS
610   $acartilage
610   $aarthritis
610   $aMMP-2
610   $aMMP-9
610   $ainhibitor
610   $aallodynia
610   $acaspase-3
610   $aneuropathic
610   $apain
610   $adorsal root ganglion
610   $aspinal nerve ligation
610   $atuberculosis
610   $atuberculous meningitis
610   $aHIV-TB-associated IRIS
610   $aextracellular matrix breakdown
610   $aadult
610   $apediatric
610   $alung
610   $acentral nervous system
610   $amatrix-metalloproteinase
610   $amonocytes
610   $ainflammation
610   $aphagocytosis
610   $aapoptosis
610   $ablood sampling
610   $aanticoagulants
610   $ahigh-molecular-weight heparin
610   $aIL-16
610   $asICAM-1
610   $aIL-8
610   $aT cells
610   $aa disintegrin and metalloproteinase
610   $aEMMPRIN
610   $aCD147
610   $aectodomain shedding
610   $aMMPs
610   $aPTMs
610   $aglycosylation
610   $aphosphorylation
610   $aglycosaminoglycans
610   $ainterleukin
610   $aIL-6
610   $aIL-11
610   $atrans-signaling
610   $ametalloproteases
610   $aADAM
610   $aMMP
610   $ameprin
610   $amatrix metalloproteinases (MMPs)
610   $aprotease
610   $asignaling
610   $ainvasion
610   $achemokine
610   $acytokine
610   $aproteomics
610   $ainterferon
610   $aAgkistrodon venom
610   $ametalloproteinase
610   $afibrinogen
610   $aantithrombotic
610   $ametabolomics
610   $aextracellular matrix
610   $acytokines
610   $aproteinases
610   $ainterstitial collagens
610   $awound healing
615  7$aResearch & information: general
615  7$aBiology, life sciences
700   $aÅgren$b Magnus S$4edt$01309861
702   $aKeller$b Ulrich$4edt
702   $aÅgren$b Magnus S$4oth
702   $aKeller$b Ulrich$4oth
906   $aBOOK
912   $a9910557717203321
996   $aMatrix Metalloproteinase$93029672
997   $aUNINA