LEADER 03573nam 2200985z- 450 001 9910557705903321 005 20210501 035 $a(CKB)5400000000046220 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68421 035 $a(oapen)doab68421 035 $a(EXLCZ)995400000000046220 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aComorbidities in Chronic Kidney Disease (CKD) 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (184 p.) 311 08$a3-03936-668-8 311 08$a3-03936-669-6 330 $aWith a mean worldwide prevalence of 13%, chronic kidney disease imposes a massive health burden on our society. In addition to reduced kidney function, patients with chronic kidney disease increasingly suffer from cardiovascular diseases affecting the heart and vasculature. Cardiovascular diseases account for around half of the deaths of patients with advanced chronic kidney disease. However, therapeutic options are highly insufficient. The pathological mechanisms that underlie increased cardiovascular risk in patients with chronic kidney disease remain largely unknown. This Special Issue provides insights into comorbidities in CKD patients, mainly focused on increased cardiovascular risk, and summarizes current knowledge of underlying pathophysiological mechanisms. 517 $aComorbidities in Chronic Kidney Disease 606 $aMedicine and Nursing$2bicssc 610 $aageing 610 $aarterial calcification 610 $aarterial stiffness 610 $abone 610 $acalcification 610 $acardiac fibrosis 610 $acardiorenal syndrome 610 $acardiovascular 610 $acardiovascular disease 610 $acarotid-femoral pulse wave velocity 610 $achronic kidney disease 610 $achronodisruption 610 $achronodisruptor 610 $acircadian rhythm 610 $aCKD 610 $aCKD-MBD 610 $acoagulation 610 $acomorbidity 610 $aend-stage kidney disease 610 $aendothelial dysfunction 610 $aepigenetics 610 $aexperimental rodent models 610 $aFGF23 610 $aFGFG23 610 $afibrosis 610 $agut 610 $aheart failure 610 $ahemodialysis 610 $ainflammation 610 $ainternal clock 610 $aklotho 610 $aKlotho 610 $aleft ventricular hypertrophy 610 $aleft-ventricular hypertrophy 610 $alipid metabolism 610 $aorgan crosstalk 610 $ap-cresyl sulfate 610 $aparathyroid hormone 610 $aphosphate 610 $apremature ageing 610 $aPTH 610 $asclerostin 610 $asecondary hyperparathyroidism 610 $asenescence 610 $auremia 610 $auremic cardiomyopathy 610 $auremic cardiopathy 610 $auremic toxin 610 $auremic toxins 610 $avascular calcification 610 $aWnt/?-catenin 615 7$aMedicine and Nursing 700 $aJankowski$b Joachim$4edt$01332367 702 $aNoels$b Heidi$4edt 702 $aJankowski$b Joachim$4oth 702 $aNoels$b Heidi$4oth 906 $aBOOK 912 $a9910557705903321 996 $aComorbidities in Chronic Kidney Disease (CKD)$93040895 997 $aUNINA