LEADER 05586nam 2201513z- 450 001 9910557705603321 005 20210501 035 $a(CKB)5400000000046223 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68639 035 $a(oapen)doab68639 035 $a(EXLCZ)995400000000046223 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNatural Products and Neuroprotection 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (338 p.) 311 08$a3-03936-216-X 311 08$a3-03936-217-8 330 $aNeurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration. 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $a5-(3,5-dihydroxyphenyl)-?-valerolactone 610 $aalgae 610 $aAlzheimer's disease 610 $aanimal studies 610 $aantioxidant 610 $aascaroside pheromone 610 $aauraptene 610 $aautophagy 610 $aB-cell lymphoma 2 610 $abeneficence 610 $abioactive compound 610 $abioavailability 610 $ablood-brain barrier 610 $aC. elegans 610 $acalcium 610 $acatechin 610 $acell death 610 $aCentella asiatica 610 $achaperones 610 $aChionanthus retusus 610 $aclinical trial 610 $acognition 610 $acognitive dysfunction 610 $acurcumin 610 $acyclic AMP 610 $adauer 610 $adepression 610 $adopamine neuron 610 $adynamics 610 $aepigallocatechin gallate 610 $aethics 610 $aflavonoid 610 $aflower 610 $afree radicals 610 $aglycogen synthase kinase 3 610 $agreen tea 610 $aheme oxygenase 610 $ahippocampus 610 $aHO-1 610 $ahormesis 610 $ahuman studies 610 $ain vitro studies 610 $ainflammation 610 $alearning 610 $aLippia citriodora 610 $amedical liability 610 $amemory 610 $amicrobiota 610 $amitochondria 610 $amitochondrial dysfunction 610 $amitophagy 610 $aMultiple Sclerosis 610 $an/a 610 $anatural compound 610 $anatural compounds 610 $anatural extract 610 $anatural products 610 $aneurodegeneration 610 $aneurodegenerative disease 610 $aneurodegenerative diseases 610 $aneuroinflammation 610 $aneuronal signaling 610 $aneuroprotection 610 $aNO 610 $anonmaleficence 610 $anutraceuticals 610 $aoxidative injury 610 $aoxidative stress 610 $aParkinson's disease 610 $aParkinson's disease (PD) 610 $apatients' autonomy 610 $aprotein aggregation 610 $aprotein poshophatase 2 610 $aproteostasis 610 $arelaxation 610 $asafety profile 610 $aseaweeds 610 $asexual behavior 610 $astress response 610 $asurvival signals 610 $asymptom 610 $asynapse loss 610 $atau protein 610 $aterpenes, rotenone 610 $athymol 610 $atype 2 diabetes 610 $aubiquitin-proteasome 610 $aubiquitin?proteasome system (UPS) 610 $aunfolded protein response 610 $avascular damage 610 $aVEE 610 $aVitamin D 610 $aVs 610 $a?-amyloid peptide 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aAngeloni$b Cristina$4edt$01299450 702 $aVauzour$b David$4edt 702 $aAngeloni$b Cristina$4oth 702 $aVauzour$b David$4oth 906 $aBOOK 912 $a9910557705603321 996 $aNatural Products and Neuroprotection$93025178 997 $aUNINA