LEADER 03841nam 2201057z- 450 001 9910557702003321 005 20220111 035 $a(CKB)5400000000046260 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76473 035 $a(oapen)doab76473 035 $a(EXLCZ)995400000000046260 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aP38 Signaling Pathway 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (194 p.) 311 08$a3-0365-0858-9 311 08$a3-0365-0859-7 330 $ap38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. 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