LEADER 03171nam 2200457z- 450 001 9910261134503321 005 20210211 035 $a(CKB)4100000002484747 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50155 035 $a(oapen)doab50155 035 $a(EXLCZ)994100000002484747 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aInduction of Central Nervous System Disease by the Adaptive Immune Response 210 $cFrontiers Media SA$d2017 215 $a1 online resource (141 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-347-2 330 $aOver the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients. 606 $aMedicine$2bicssc 610 $aaquaporin-4 610 $aautoimmune encephalitis 610 $aautophagy 610 $aB cells 610 $amultiple sclerosis 610 $amyelin oligodendrocyte glycoprotein 610 $aneuromyelitis optica spectrum disorder 610 $aNMDA receptor 610 $aT cell 610 $athyroid gland 615 7$aMedicine 700 $aFabienne Brilot$4auth$01311260 702 $aRobert Weissert$4auth 906 $aBOOK 912 $a9910261134503321 996 $aInduction of Central Nervous System Disease by the Adaptive Immune Response$93030067 997 $aUNINA LEADER 04246nam 2201297z- 450 001 9910557693703321 005 20210501 035 $a(CKB)5400000000044594 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68305 035 $a(oapen)doab68305 035 $a(EXLCZ)995400000000044594 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvanced Coatings for Corrosion Protection 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (222 p.) 311 08$a3-03943-921-9 311 08$a3-03943-922-7 330 $aCorrosion is a significant issue in many industrial fields. Among other strategies, coatings are by far the most important technology for corrosion protection of metallic surfaces. The Special Issue "Advanced Coatings for Corrosion Protection" has been launched as a means to present recent developments in any type of advanced coating for corrosion protection. This book compiles 15 contributions on metallic, inorganic, polymeric and nanoparticle enhanced coatings that provide corrosion protection as well as other functionalities. 606 $aResearch and information: general$2bicssc 610 $aaging mechanism 610 $aAl2O3 coating 610 $aaluminum alloy AlMg6 610 $aaluminum foam 610 $aanodizing layers 610 $aapatite 610 $aboride-based cermet 610 $acarburization 610 $acathodic protection 610 $acavitation 610 $achemical properties 610 $acoating 610 $acoating selection 610 $acold galvanized coating 610 $acomposite coatings 610 $acompression test 610 $acorrosion 610 $acorrosion behavior 610 $acorrosion mechanism 610 $acorrosion mitigation method 610 $acorrosion protection 610 $acorrosion resistance 610 $adurability 610 $aelectrochemical corrosion behavior 610 $aelectrochemical noise 610 $aelectrochemistry 610 $aelectrodeposition 610 $aerosion 610 $afluorine free 610 $ahardness 610 $ahydrogen bond 610 $ahydrogen permeation 610 $aintergranular corrosion 610 $alaser cladding 610 $alaser cladding synthesis 610 $alaser power 610 $amagnesium 610 $amagnesium alloy 610 $aMAO coating 610 $amarine environments 610 $aMAX phase 610 $amechanical energy aided diffusion 610 $ametallic coatings 610 $amicro-arc oxidation 610 $amicrostructure 610 $amolecular dynamics 610 $amorphology 610 $an/a 610 $aNi-Fe-Co-P-CeO2 composite coating 610 $aoxidation 610 $apassivated 610 $apassivation 610 $aphase composition 610 $aphase separation 610 $apitting corrosion 610 $apolarization 610 $apolymer 610 $apolymeric coatings 610 $apolyurea 610 $apotentiodynamic polarization test 610 $apre-insulated pipeline 610 $aprecipitation hardening 610 $aPVD 610 $aPVD coating 610 $ascanning electrodeposition 610 $aself-cleaning 610 $asilanization 610 $asimulation 610 $astainless steel 610 $astratification phenomena 610 $astress corrosion 610 $asuperhydrophobic 610 $asuperhydrophobic coatings 610 $aTi2AlN 610 $atungsten 610 $aW-Cr-C coating 610 $awater hydraulic valve 610 $awear resistance 610 $azinc-rich coating 610 $aZn-Al diffusion layer 615 7$aResearch and information: general 700 $aFu?rbeth$b Wolfram$4edt$01134567 702 $aFu?rbeth$b Wolfram$4oth 906 $aBOOK 912 $a9910557693703321 996 $aAdvanced Coatings for Corrosion Protection$93028867 997 $aUNINA