LEADER 03998nam 2200937z- 450 001 9910557681103321 005 20231214133046.0 035 $a(CKB)5400000000044721 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76671 035 $a(EXLCZ)995400000000044721 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSynthesis of Marine Natural Products and Molecules Inspired by Marine Substances 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (147 p.) 311 $a3-0365-1768-5 311 $a3-0365-1767-7 330 $aMarine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances. 606 $aLanguage$2bicssc 610 $aorganic synthesis 610 $ameroterpenoids 610 $athiazinoquinones 610 $aantiproliferative activity 610 $aG0/G1 cell-cycle arrest 610 $acytostatic 610 $asolid tumor cell lines 610 $aalkylglycerol (AKG) 610 $aricinoleic acid (RA) 610 $aantimicrobial activity 610 $astructure-activity relationship (SAR) studies 610 $aantibiotics (gentamicin 610 $atetracycline 610 $aciprofloxacin and ampicillin) 610 $amarine-inspired 610 $abreast cancer 610 $abis-indoles 610 $asynthesis 610 $aapoptosis 610 $acarbohydrates 610 $apolysaccharides 610 $asemi-synthesis 610 $asulfation 610 $aglycosylation 610 $afucose 610 $afucosylated chondroitin sulfate 610 $amarine natural product 610 $alargazole 610 $aHDAC inhibitors 610 $amodification 610 $afluoro olefin 610 $atotal synthesis 610 $anatural product 610 $a7-deazapurine nucleoside 610 $adisaccharide nucleoside 610 $atubercidin 610 $aaureol 610 $atetracyclic meroterpenoids 610 $anatural products synthesis 610 $alabdane scaffold 610 $abioactive diterpenes 610 $asclareolide 610 $astructure-activity relationships 610 $aTRPV4 channel 610 $aamides/esters 610 $aCOVID-19 610 $aSARS-CoV-2 610 $alipophilic iminosugars 610 $apolymer-supported triphenyl phosphine 610 $acholesterol 610 $aantibacterial iminosugars 615 7$aLanguage 700 $aManzo$b Emiliano$4edt$01291001 702 $aManzo$b Emiliano$4oth 906 $aBOOK 912 $a9910557681103321 996 $aSynthesis of Marine Natural Products and Molecules Inspired by Marine Substances$93021740 997 $aUNINA