LEADER 01149nam 22003973 450 001 9910130480503321 005 20090608000000.0 010 $a88-6056-133-7 035 $a(CKB)3400000000019832 035 $a(ItFiC)it 02414160 035 $a(EXLCZ)993400000000019832 100 $a20101102d2009 uy 0 101 0 $aita 200 13$aIl patto germano-sovietico $ela storia e la leggenda /$fAngelo Tasca ; traduzione commento introduzione, Michele Millozzi 205 $a1. ed. 210 $aMacerata $cEUM$d2009 215 $axxx, 131 p. ;$d22 cm 225 0$aStoria.$pCultura 300 $aOrig. title: Le pacte germano-soviétique. 300 $aTransl. by M. Millozzi. 320 $aIncludes bibliographical references. 517 $aPatto germano-sovietico 517 $aIl patto germano-sovietico 676 $a327 676 $a321 676 $a940 676 $a947 676 $a943 676 $a324 700 $aTasca$b Angelo$f1892-1960.$014237 801 0$bItFiC 801 1$bItFiC 906 $aBOOK 912 $a9910130480503321 996 $aIl patto germano-sovietico$92439793 997 $aUNINA LEADER 04515nam 2200481z- 450 001 9910557662003321 005 20211118 035 $a(CKB)5400000000044886 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73704 035 $a(oapen)doab73704 035 $a(EXLCZ)995400000000044886 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aShaping the Brain by Neuronal Cytoskeleton: From Development to Disease and Regeneration 210 $cFrontiers Media SA$d2020 215 $a1 online resource (185 p.) 311 08$a2-88963-552-X 330 $aThe coordinated action of the different cytoskeletal polymers--microtubules, actin filaments and neurofilaments-- is essential for the establishment, remodeling and maintenance of neuronal architecture throughout the neuron lifetime. Neurons are among the most polarized cells, with a long thin axon and multiple thicker and shorter dendrites. Achieving this complex morphology, and the precise and accurate formation of an intricate network of synaptic contacts is critical for the proper transmission and reception of signals in the brain. Neuronal polarization precedes axon outgrowth and the subsequent differentiation of short neurites into dendrites, as part of the neuronal differentiation program that involves both intrinsic and extrinsic signals that converge at the cytoskeletal level. Growth cones, which are sensory and locomotor structures located at the tip of growing axons, are key elements in the transduction of extracellular cues into cytoskeletal changes, guiding axons to their right destinations. Neuronal migration, another crucial process during brain development, occurs in close coordination with neuronal differentiation. Migration involves as well an extensive rearrangement of neuronal cell shape that relies on cytoskeleton reorganization. Further processes, such as dendritic spine formation and growth, establishment of synaptic contacts or synaptic plasticity in mature neurons also depend on cytoskeletal dynamics. Fine-tune regulation of neuronal cytoskeleton is therefore crucial for the maintenance of neuronal integrity and functionality. Mutations in genes that code for cytoskeletal proteins often have deleterious effects in neurons, such as abnormal migration or differentiation, deficient axonal transport of organelles and synaptic vesicles, or impaired synaptic signaling. Several human Nervous System disorders, including neurodevelopmental, psychiatric, and neurodegenerative diseases, have been linked to cytoskeletal dysfunction. Cytoskeletal reorganization is also crucial to regulate nerve cell repair following Nervous System injury. Many of the pathways that control cell-intrinsic axon regeneration lead to axon cytoskeletal remodeling. Moreover, most extracellular cues that inhibit regeneration of damaged axons in Central Nervous System following traumatic injury or neurodegeneration, are known to modulate cytoskeletal dynamics and organization. Based on these findings, regulators of cytoskeleton dynamics have emerged as promising therapeutic targets in several brain disorders and in the context of regeneration of injured axons. Hence, remodeling of neuronal cytoskeleton underlies all the dramatic morphological changes that occur in developing and adult neurons. Understanding the specific molecular mechanisms that control cytoskeleton rearrangements in neurons is far from complete. This Frontiers Research Topic gathers a selection of articles focused on the diverse and key roles of cytoskeleton in neuronal biology. 517 $aShaping the Brain by Neuronal Cytoskeleton 606 $aNeurosciences$2bicssc 606 $aScience: general issues$2bicssc 610 $aactin cytoskeleton 610 $aastrocyte cytoskeleton 610 $amicrotubules (MTs) 610 $aneuron 610 $aneuronal cytoskeleton 610 $atau 615 7$aNeurosciences 615 7$aScience: general issues 700 $aLaura Sayas$b C$4edt$01302165 702 $aMendes Sousa$b Monica$4edt 702 $aAvila$b Jesus$4edt 702 $aLaura Sayas$b C$4oth 702 $aMendes Sousa$b Monica$4oth 702 $aAvila$b Jesus$4oth 906 $aBOOK 912 $a9910557662003321 996 $aShaping the Brain by Neuronal Cytoskeleton: From Development to Disease and Regeneration$93026187 997 $aUNINA