LEADER 03057nam 2200457z- 450 001 9910557622203321 005 20211118 035 $a(CKB)5400000000045193 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73716 035 $a(oapen)doab73716 035 $a(EXLCZ)995400000000045193 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCurrent Perspectives, Challenges and Advances in Cell Based Therapies 210 $cFrontiers Media SA$d2020 215 $a1 online resource (192 p.) 311 08$a2-88963-564-3 330 $aCell-based immunotherapy is based on the seemingly simple principle of harnessing the power of the immune system to combat cancer, and is emerging as an important clinical tool. The remarkable success of CAR-T cell therapies demonstrate that cell based therapies are effective at eradicating hematological malignancies, and therefore hold great promise for other cancers. However, there are number of challenges that limit the full potential of cell based therapies, especially for solid cancers. T cells and NK cells represent major lymphocyte populations that are involved in immune surveillance and tumor eradication, and both are emerging as important players for cell based immunotherapy. Although they use different mechanisms for recognizing cancer cells, they complement each other during tumor eradication. NK cells have many functional similarities to T cells and represent the closest innate immune cell lineage to adaptive immune cell populations. Transcriptome analysis has also revealed similar phylogenetic origin of the two lymphocyte populations. The hurdles that impact therapeutic success of these cells include trafficking of lymphocytes to the tumor sites, recognition of solid tumors, and overcoming the inhospitable tumor microenvironment (TME) including the presence of suppressive cells (Treg and MDSC) and immune suppressive cytokines (TGF?). The full potential of cell based therapies may be realized once tools to overcome these barriers are developed. This Research Topic collects articles critically examining these obstacles and the novel strategies being developed for cell-based therapies to overcome them. 606 $aMedicine and Nursing$2bicssc 606 $aOncology$2bicssc 610 $aCAR (chimeric antigen receptor) T cells 610 $acell based therapy 610 $aimmunotherapy 610 $aNK cell 610 $atumor micoenvironment 615 7$aMedicine and Nursing 615 7$aOncology 700 $aTrikha$b Prashant$4edt$01286917 702 $aThakar$b Monica$4edt 702 $aRussell Cruz$b Conrad$4edt 702 $aTrikha$b Prashant$4oth 702 $aThakar$b Monica$4oth 702 $aRussell Cruz$b Conrad$4oth 906 $aBOOK 912 $a9910557622203321 996 $aCurrent Perspectives, Challenges and Advances in Cell Based Therapies$93019993 997 $aUNINA