LEADER 00997nam a2200241 i 4500 001 991002065639707536 008 130524e2007 it 000 0 ita 020 $a9788846488350 035 $ab14115475-39ule_inst 040 $aDip.to di Storia, Societą e Studi sull'Uomo - Sez. Studi Storici$bita 082 04$a338.09458 245 04$aGli archivi d'impresa in Sicilia :$buna risorsa per la conoscenza e lo sviluppo del territorio /$ca cura di Gaetano Calabrese 260 $aMilano :$bFrancoAngeli,$c[2007] 300 $a265 p. ;$c23 cm. 440 0$aStudi e ricerche di storia dell'editoria 650 4$aImprese$xArchivi$zSicilia 700 1 $aCalabrese, Gaetano 907 $a.b14115475$b02-04-14$c24-05-13 912 $a991002065639707536 945 $aLE023 338.094 ARC 1 1 $g1$i2023000161920$lle023$og$pE21.00$q-$rl$s- $t0$u1$v0$w1$x0$y.i15512848$z24-05-13 996 $aArchivi d'impresa in Sicilia$9263997 997 $aUNISALENTO 998 $ale023$b24-05-13$cm$da $e-$fita$git $h4$i0 LEADER 05308nam 2200649 450 001 9910810322803321 005 20200520144314.0 010 $a1-119-05858-9 010 $a1-119-05807-4 010 $a1-119-05798-1 035 $a(CKB)3710000000315823 035 $a(EBL)1890998 035 $a(SSID)ssj0001432365 035 $a(PQKBManifestationID)11852772 035 $a(PQKBTitleCode)TC0001432365 035 $a(PQKBWorkID)11388889 035 $a(PQKB)11095169 035 $a(MiAaPQ)EBC1890998 035 $a(Au-PeEL)EBL1890998 035 $a(CaPaEBR)ebr10997825 035 $a(OCoLC)898213751 035 $a(EXLCZ)993710000000315823 100 $a20150106h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDiscrete mechanics /$fJean-Paul Caltagirone 210 1$aLondon, England ;$aHoboken, New Jersey :$cISTE :$cWiley,$d2015. 210 4$d©2015 215 $a1 online resource (253 p.) 225 1 $aFluid Mechanics Series 300 $aDescription based upon print version of record. 311 $a1-84821-678-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Copyright; Contents; Preface; List of Symbols; Introduction; I.1. General points; I.2. Introduction; 1: Framework of Discrete Mechanics; 1.1. Frames of reference and uniform motions; 1.2. Concept of a Discrete Medium; 1.2.1. Vectors and components; 1.2.2. Physical meaning of the differential operators; 1.2.3. Use of the theorems of differential geometry; 1.2.4. Two essential properties; 1.2.5. Tensorial values; 1.2.6. The scalar and vectorial potentials; 1.3. The physical characteristics; 1.4. Equilibrium stress state; 1.4.1. Two examples of mechanical equilibrium 327 $a1.5. Thermodynamic non-equilibrium1.5.1. Forces and fluxes; 1.6. Conservation of mass; 2: Momentum Conservation; 2.1. Classification of forces; 2.2. Three fundamental experiments; 2.2.1. Equilibrium in a glass of water; 2.2.2. Couette flow; 2.2.3. Poiseuille flow; 2.3. Postulates; 2.4. Modeling of the pressure forces; 2.5. Modeling of the viscous forces; 2.5.1. Modeling of the viscous effects of volume; 2.5.2. Modeling of the viscous surface effects; 2.5.3. Stress state; 2.6. Objectivity; 2.7. Discrete motion balance equation; 2.7.1. Fundamental law of dynamics; 2.7.2. Eulerian step 327 $a2.7.3. Mechanical equilibrium2.8. Formulation in terms of density and temperature; 2.9. Similitude parameters; 2.9.1. Impact on the surface of a liquid; 2.10. Hypercompressible media; 3: Conservation of Heat Flux and Energy; 3.1. Introduction; 3.2. Conservation of flux; 3.3. Conservation of energy; 3.3.1. Conservation of total energy; 3.3.2. Conservation of kinetic energy; 3.3.3. Conservation of the internal energy; 3.4. Discrete equations for the flux and the energy; 3.5. A simple heat-conduction problem; 3.5.1. Case of anisotropic materials; 4: Properties of Discrete Equations 327 $a4.1. A system of equations and potentials4.2. Physics represented; 4.2.1. Poiseuille flow and potentials; 4.2.2. Celerity and maximum velocity; 4.2.3. Remarks about turbulence; 4.3. Boundary conditions; 4.3.1. Contact surface; 4.3.2. Shockwaves; 4.3.3. Edge conditions; 4.3.4. Slip condition; 4.3.5. Capillary effects; 4.3.6. Thermal boundary conditions; 4.4. Penalization of the potentials; 4.5. Continua and discrete mediums; 4.5.1. Differences with the Navier-Stokes equation; 4.5.2. Dissipation; 4.5.3. Case of rigidifying motions; 4.5.4. An example of the dissipation of energy 327 $a4.6. Hodge-Helmholtz decomposition4.7. Approximations; 4.7.1. Bernoulli's law; 4.7.2. Irrotational flow; 4.7.3. Inviscid fluid; 4.7.4. Incompressible flow; 4.8. Gravitational waves; 4.9. Linear visco-elasticity; 4.9.1. Viscous dissipation in a visco-elastic medium; 4.9.2. Dissipation of longitudinal waves in a visco-elastic medium; 4.9.3. Consistency with Continuum Mechanics; 4.9.4. Pure compression; 4.9.5. Pure shear stress; 4.9.6. Bingham fluid; 5: Multiphysics; 5.1. Extensions to other branches of physics; 5.1.1. Coupling between a fluid and a porous medium 327 $a5.2. Flow around a cylinder in an infinite medium 330 $aThis book presents the fundamental principles of mechanics to re-establish the equations of Discrete Mechanics. It introduces physics and thermodynamics associated to the physical modeling. The development and the complementarity of sciences lead to review today the old concepts that were the basis for the development of continuum mechanics. The differential geometry is used to review the conservation laws of mechanics. For instance, this formalism requires a different location of vector and scalar quantities in space. The equations of Discrete Mechanics form a system of equations where the H 410 0$aFluid mechanics series. 606 $aMechanics, Analytic 606 $aNonlinear mechanics 615 0$aMechanics, Analytic. 615 0$aNonlinear mechanics. 676 $a531.01515 700 $aCaltagirone$b Jean-Paul$0895423 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810322803321 996 $aDiscrete mechanics$94035975 997 $aUNINA LEADER 03057nam 2200457z- 450 001 9910557622203321 005 20211118 035 $a(CKB)5400000000045193 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73716 035 $a(oapen)doab73716 035 $a(EXLCZ)995400000000045193 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCurrent Perspectives, Challenges and Advances in Cell Based Therapies 210 $cFrontiers Media SA$d2020 215 $a1 online resource (192 p.) 311 08$a2-88963-564-3 330 $aCell-based immunotherapy is based on the seemingly simple principle of harnessing the power of the immune system to combat cancer, and is emerging as an important clinical tool. The remarkable success of CAR-T cell therapies demonstrate that cell based therapies are effective at eradicating hematological malignancies, and therefore hold great promise for other cancers. However, there are number of challenges that limit the full potential of cell based therapies, especially for solid cancers. T cells and NK cells represent major lymphocyte populations that are involved in immune surveillance and tumor eradication, and both are emerging as important players for cell based immunotherapy. Although they use different mechanisms for recognizing cancer cells, they complement each other during tumor eradication. NK cells have many functional similarities to T cells and represent the closest innate immune cell lineage to adaptive immune cell populations. Transcriptome analysis has also revealed similar phylogenetic origin of the two lymphocyte populations. The hurdles that impact therapeutic success of these cells include trafficking of lymphocytes to the tumor sites, recognition of solid tumors, and overcoming the inhospitable tumor microenvironment (TME) including the presence of suppressive cells (Treg and MDSC) and immune suppressive cytokines (TGF?). The full potential of cell based therapies may be realized once tools to overcome these barriers are developed. This Research Topic collects articles critically examining these obstacles and the novel strategies being developed for cell-based therapies to overcome them. 606 $aMedicine and Nursing$2bicssc 606 $aOncology$2bicssc 610 $aCAR (chimeric antigen receptor) T cells 610 $acell based therapy 610 $aimmunotherapy 610 $aNK cell 610 $atumor micoenvironment 615 7$aMedicine and Nursing 615 7$aOncology 700 $aTrikha$b Prashant$4edt$01286917 702 $aThakar$b Monica$4edt 702 $aRussell Cruz$b Conrad$4edt 702 $aTrikha$b Prashant$4oth 702 $aThakar$b Monica$4oth 702 $aRussell Cruz$b Conrad$4oth 906 $aBOOK 912 $a9910557622203321 996 $aCurrent Perspectives, Challenges and Advances in Cell Based Therapies$93019993 997 $aUNINA