LEADER 03678nam 2200793z- 450 001 9910557615903321 005 20231214133328.0 035 $a(CKB)5400000000045243 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/79571 035 $a(EXLCZ)995400000000045243 100 $a20202203d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOligonucleotide, Therapy, and Applications 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (123 p.) 311 $a3-0365-3057-6 311 $a3-0365-3056-8 330 $aOligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs. 606 $aMedicine$2bicssc 610 $aquantum dots (QDs) 610 $aDNAzyme 610 $aROS 610 $aAmplex Red 610 $alight-induced activity 610 $aDNA methylation 610 $ahistone code 610 $amicroRNA 610 $ananoparticles 610 $anoncoding RNA 610 $apulmonary arterial hypertension 610 $aaptamer 610 $aaptasensor 610 $ainfluenza 610 $aSERS 610 $avirus detection 610 $a?-synuclein 610 $aantisense oligonucleotide 610 $adopamine neurotransmission 610 $adouble mutant A30P*A53T* 610 $amotor deficits 610 $aParkinson?s disease 610 $atransgenic mouse model 610 $aG-quadruplexes 610 $acovalent dimer construct 610 $aanti-proliferative activity 610 $aprimary cell culture of human glioma 610 $aantisensense oligonucleotide 610 $aFoxp3 610 $aregulatory T cells 610 $avaccine immunogenicity 610 $aSporothrix schenckii 610 $aMarfan syndrome 610 $afibrillin-1 610 $aantisense oligonucleotides 610 $aexon skipping 610 $asplice-switching 615 7$aMedicine 700 $aAliño$b Salvador$4edt$01303482 702 $aSendra$b Luis$4edt 702 $aAliño$b Salvador$4oth 702 $aSendra$b Luis$4oth 906 $aBOOK 912 $a9910557615903321 996 $aOligonucleotide, Therapy, and Applications$93027103 997 $aUNINA