LEADER 04811nam 2201369z- 450 001 9910557609003321 005 20240528190146.0 035 $a(CKB)5400000000045312 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/79672 035 $a(EXLCZ)995400000000045312 100 $a20202203d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNew Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (272 p.) 311 $a3-0365-3358-3 311 $a3-0365-3357-5 330 $aThis book includes 17 papers published in the Special Issue/Article Collection ?New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas? including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University). 606 $aMedicine$2bicssc 610 $apheochromocytoma 610 $aparaganglioma 610 $agenetics 610 $anon-coding RNA 610 $amalignancy 610 $abiomarker 610 $atreatment 610 $aadaptive metabolism 610 $aadrenal gland 610 $aconn adenoma 610 $afatty acid metabolism 610 $aferroptosis 610 $ahyperaldosteronism 610 $ametabolic reprogramming 610 $a?-oxidation 610 $aPPAR? 610 $atumor microenvironment 610 $aNext Generation Sequencing 610 $ahereditary cancer 610 $aendocrine tumor syndrome 610 $aKCNJ5 somatic mutation 610 $apulse wave velocity 610 $aaldosterone-producing adenoma 610 $aadrenalectomy 610 $apropensity score matching 610 $aarterial stiffness 610 $apheochromocytomas 610 $aparagangliomas 610 $amutations 610 $asusceptibility genes 610 $adriver mutations 610 $ahereditary 610 $agermline 610 $asomatic 610 $aenvironment 610 $avariants 610 $atumor suppressor genes 610 $ametastatic 610 $aRNAseq 610 $anext generation sequencing 610 $aadrenocortical carcinoma 610 $ain silico analysis 610 $amachine learning 610 $abioinformatic clustering 610 $abiomarker prediction 610 $aaldosterone producing adenoma 610 $aATP2B3 610 $aK416-F418delinsN mutation 610 $aprimary aldosteronism 610 $aPPGL 610 $atelomeres 610 $aTERT 610 $aATRX 610 $aNOP10 610 $aprognostic biomarker 610 $aALT 610 $aphaeochromocytoma 610 $acancer 610 $amitochondrial complex II 610 $azebrafish 610 $atherapy 610 $adrug discovery 610 $aredox balance pathway 610 $aVitamin C 610 $amitotane 610 $aH295 strains 610 $amicroRNA 610 $aaldosterone 610 $acirculating 610 $aadrenocortical 610 $atranscriptomics 610 $aepigenetics 610 $ametabolomics 610 $aepidemiology 610 $agenetic analysis 610 $amortality 610 $asurveillance 610 $aTP53 R337H 610 $agenetic testing 610 $aadrenocortical tumor 610 $aneonatal screening 610 $ascreening 610 $aadenoma 610 $aadrenal 610 $atissue 610 $aartificial intelligence 610 $aneural network 615 7$aMedicine 700 $aIgaz$b Peter$4edt$01082320 702 $aIgaz$b Peter$4oth 906 $aBOOK 912 $a9910557609003321 996 $aNew Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas$93027446 997 $aUNINA