LEADER 04168nam 2201141z- 450 001 9910557600303321 005 20231214133342.0 035 $a(CKB)5400000000043674 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68319 035 $a(EXLCZ)995400000000043674 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (232 p.) 311 $a3-03943-376-8 311 $a3-03943-377-6 330 $aAggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence potential of the isolated bacteria, genetic profiling is recommended. Advanced knowledge of the virulence mechanisms induced by this bacterium is important for the development of future personalized preventive and treatment strategies. The fifteen papers in this book provide a strong and relevant background that can contribute to the improvement of future diagnosis and research strategies. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $aAggregatibacter actinomycetemcomitans 610 $acagE 610 $avirB1 610 $avirB4 610 $agenotype 610 $avirulence 610 $amRNA assay 610 $aquantitative ELISA 610 $acell lysis assay 610 $aleukotoxin 610 $aJP2 genotype 610 $acytolethal distending toxin 610 $alipopolysaccharides 610 $acytokine binding factors 610 $ahorizontal gene transfer 610 $aouter membrane vesicles 610 $abiofilm 610 $aproteomic 610 $aadherence 610 $aendocarditis 610 $afimbriae 610 $aJP2 610 $aperiodontitis 610 $ataxonomy 610 $acore and accessory genes 610 $aaverage nucleotide identity 610 $aprincipal component analysis 610 $akeratins 610 $aorganotypic gingival mucosa 610 $aA. actinomycetemcomitans 610 $aRNA-Seq 610 $agenomic islands 610 $acore genes 610 $aaccessory genes 610 $astress 610 $anutrient limitation 610 $adifferentially expressed genes. 610 $alymphocytes 610 $aapoptosis 610 $aRTX toxin 610 $alocalized aggressive periodontitis 610 $aLFA-1 610 $aleukotoxin (LtxA) 610 $aendocytosis 610 $aJP2 clone of Aggregatibacter actinomycetemcomitans 610 $aJP2 in Caucasian 610 $amicrobiological diagnosis 610 $aadjunctive antibiotics 610 $alocalized aggressive periodontitis: animal studies: human studies 610 $alandscape ecology 610 $adamage/response framework 610 $abacteremia 610 $ahorseshoe crab 610 $aOriganum vulgare 610 $aessential oil 610 $aantimicrobial activity 610 $aminimum inhibitory concentration 610 $aminimal bactericidal concentration 610 $acytotoxicity 610 $aleukotoxin neutralization 610 $ainflammasome 610 $aimmune response 610 $aperiodontal disease 610 $aproteomics 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aJohansson$b Anders$4edt$01161470 702 $aDiRienzo$b Joseph M$4edt 702 $aJohansson$b Anders$4oth 702 $aDiRienzo$b Joseph M$4oth 906 $aBOOK 912 $a9910557600303321 996 $aAggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen$93019562 997 $aUNINA