LEADER 04291nam 2200961z- 450 001 9910557595603321 005 20231214133446.0 035 $a(CKB)5400000000043721 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76802 035 $a(EXLCZ)995400000000043721 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMarine Natural Products as Anticancer Agents 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (150 p.) 311 $a3-0365-1820-7 311 $a3-0365-1819-3 330 $aCancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment. 606 $aMedicine$2bicssc 610 $aalga 610 $amarine-derived fungus 610 $aPenicillium chrysogenum 610 $apolyketide 610 $ahydroxyphenylacetic acid 610 $acytotoxicity 610 $aflaccidoxide-13-acetate 610 $ahepatocellular carcinoma 610 $ainvasion 610 $amigration 610 $aepithelial-mesenchymal transition 610 $aprostate cancer 610 $aastaxanthin 610 $aSTAT3 610 $aproliferation 610 $acolony formation 610 $aapoptosis 610 $aSarcophyton digitatum 610 $abiscembranoid-type metabolites 610 $ainflammatory factor production 610 $aLPS-stimulated murine macrophage 610 $aEhlich's tumor 610 $aP. purpurogenum 610 $aantitumor 610 $ameroterpenoids 610 $ainflammation 610 $aT47D 610 $aBT20 610 $apontin 610 $amutp53 610 $acancer stem cells 610 $aOct4 610 $aNanog 610 $asiRNA 610 $asecondary metabolites 610 $aepigenome 610 $aepigenetic signaling 610 $abioactive compounds 610 $acancer therapy 610 $amarine species 610 $aenvironment 610 $atotal synthesis 610 $anatural product 610 $anannocystin 610 $aanti-cancer 610 $agram-scale 610 $aaplysinopsin analogs 610 $aindole alkaloids 610 $amarine source 610 $achronic myeloid leukemia 610 $aBH3 mimetics 615 7$aMedicine 700 $aAlves$b Celso$4edt$01304461 702 $aDiederich$b Marc$4edt 702 $aAlves$b Celso$4oth 702 $aDiederich$b Marc$4oth 906 $aBOOK 912 $a9910557595603321 996 $aMarine Natural Products as Anticancer Agents$93027442 997 $aUNINA