LEADER 06841nam 2201969z- 450 001 9910557577203321 005 20231214132952.0 035 $a(CKB)5400000000043877 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69023 035 $a(EXLCZ)995400000000043877 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMitochondria in Health and Diseases 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (434 p.) 311 $a3-03936-384-0 311 $a3-03936-385-9 330 $aMitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients. 606 $aMedicine$2bicssc 610 $ahypoglycemia 610 $asodium dichloroacetate 610 $apyruvate dehydrogenase kinase 610 $apyruvate dehydrogenase 610 $aoxidative stress 610 $aneuron death 610 $acholangiocellular carcinoma 610 $amitochondria 610 $aenergy metabolism 610 $aoxidative phosphorylation 610 $a4-HNE 610 $aDRP1 610 $aERK1/2 610 $ahippocampus 610 $aJNK 610 $amitochondrial dynamics 610 $aPKA 610 $aprotein phosphatases 610 $aTUNEL 610 $aDDE 610 $ahigh-fat diet 610 $amitochondrial UCP2 610 $aROS 610 $aantioxidant system 610 $auncoupling protein 610 $amitochondria: energy metabolism 610 $alipid handling 610 $afatty acid oxidation 610 $apotassium channel 610 $areactive oxygen species 610 $aantioxidants 610 $alife span 610 $aaging 610 $aBKCa channels 610 $apravastatin 610 $agemfibrozil 610 $aliver 610 $acolon 610 $amitochondrial function 610 $acyclosporin A 610 $amitochondria calcium buffering 610 $amitochondria bioenergetics 610 $amitochondria permeability transition pore 610 $ainorganic phosphate 610 $ahepatic fibrogenesis 610 $aHtrA2/Omi 610 $areactive oxygen species stress 610 $amitochondrial homeostasis 610 $acomplex I (CI) deficiency 610 $ametabolome and proteome profiling 610 $areactive oxygen species (ROS) 610 $arespirasome assembly 610 $aelectron tunneling (ET) 610 $aperilipin 5 610 $alipid droplet 610 $aH9c2 cardiomyoblasts 610 $aadenine nucleotide translocase 610 $arespiratory supercomplexes 610 $aETC complexes 610 $adentate granule cell 610 $aepilepsy 610 $ahyperforin 610 $aLONP1 610 $aneuroprotection 610 $apilocarpine 610 $aseizure 610 $asiRNA 610 $acardioprotection 610 $amitochondrial permeability transition pores 610 $amitochondrial connexin 43 610 $acardiolipin 610 $airon overload 610 $ahepcidin 610 $atransferrin 610 $aferritin 610 $aZIP 610 $ainflammation 610 $amtDNA 610 $amitochondrial dysfunction 610 $amuscle aging 610 $aphysical performance 610 $aLHON 610 $aSiberian population 610 $aancient mutation 610 $aspecific genetic background 610 $aapoptosis 610 $ahuman amniotic membrane 610 $amitochondrial cell death 610 $aBAX 610 $aBCL-2 610 $atensile strength 610 $amitochondrial gene expression 610 $amtDNA transcription 610 $amtRNA 610 $apost-transcriptional mtRNA processing 610 $adsRNA 610 $ainnate immunity 610 $ainterferon response 610 $aamino acid neurotransmitter 610 $acerebellar amino acid metabolism 610 $ahypoxia 610 $a2-oxoglutarate dehydrogenase 610 $atricarboxylic acid cycle 610 $aheart 610 $acytoskeletal proteins 610 $amitochondrial interactions 610 $aplectin 610 $atubulin beta 610 $asignaling 610 $aGW9662 610 $aischemia reperfusion injury 610 $aLangendorff 610 $amyocardial 610 $apioglitazone 610 $aredox state 610 $arosiglitazone 610 $aTZD 610 $auncoupling 610 $aADP/ATP carrier 610 $aKmADP 610 $adextran 610 $amorphology 610 $acardiomyocytes 610 $atelomere length 610 $atelomerase activity 610 $adevelopment 610 $aregeneration 610 $aintranuclear mitochondria 610 $ahealthy cells 610 $aelectron and confocal microscopy 610 $asignaling pathways 610 $aion homeostasis 610 $ahuman diseases 615 7$aMedicine 700 $aJavadov$b Sabzali$4edt$01280541 702 $aKozlov$b Andrey V$4edt 702 $aCamara$b Amadou K.S$4edt 702 $aJavadov$b Sabzali$4oth 702 $aKozlov$b Andrey V$4oth 702 $aCamara$b Amadou K.S$4oth 906 $aBOOK 912 $a9910557577203321 996 $aMitochondria in Health and Diseases$93017189 997 $aUNINA