LEADER 06761nam 2201849z- 450 001 9910557577003321 005 20231214133002.0 035 $a(CKB)5400000000043879 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77168 035 $a(EXLCZ)995400000000043879 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCoumarin and Its Derivatives 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (406 p.) 311 $a3-0365-2775-3 311 $a3-0365-2774-5 330 $aCoumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $acoumarin 610 $ahydroxyl-modified coumarin 610 $aphotophysical 610 $athermal and structural characterization 610 $aGlycyrrhiza uralensis 610 $aglycyrol 610 $aliquiritigenin 610 $acholinesterases 610 $ahuman monoamine oxidases 610 $akinetics 610 $adocking simulation 610 $achalcone 610 $aneurodegenerative diseases 610 $aadenosine receptors 610 $abinding affinity 610 $adocking 610 $a4-hydroxy-7-methoxycoumarin 610 $amacrophage 610 $ainflammation 610 $aNF-?B 610 $aMAPK 610 $acalanolides 610 $apseudocalanolides 610 $acalanolide A 610 $aCalophyllum 610 $aCalophyllaceae 610 $aanti-HIV 610 $areverse transcriptase 610 $anon-nucleoside reverse transcriptase inhibitors (NNRTIs) 610 $aosthole 610 $aumbelliferone 610 $aesculin 610 $a4-hydroxycoumarin 610 $asorafenib 610 $aapoptosis 610 $aautophagy 610 $aYin Chen Hao 610 $aconstitutive androstane receptor 610 $ascoparone 610 $acoumarins 610 $aquorum sensing 610 $aQS inhibitors 610 $aplant-derived molecules 610 $aChromobacterium violaceum 610 $aimmunoproteasome 610 $apsoralen core 610 $anon-peptidic 610 $aelectrophilic compounds 610 $awarhead scan 610 $ainflammatory bowel disease 610 $aisocoumarin 610 $aCrohn's disease 610 $aulcerative colitis 610 $aglutathione 610 $aoxidative stress 610 $acomplementary therapies 610 $aintestinal inflammation 610 $abenzopyrones 610 $afive-membered aromatic heterocycles 610 $afuran 610 $apyrrole 610 $athiophene 610 $aselenophen 610 $adihydrocoumarin-fused dihydropyranones 610 $a3-aroylcoumarines 610 $abenzyl 2,3-butadienoate 610 $a6'-(4-biphenyl)-?-iso-cinchonine 610 $abiological applications 610 $adrug discovery 610 $afluorescent probes 610 $awarfarin 610 $aacenocoumarol 610 $amechanical valve 610 $atime in therapeutic range 610 $aanticoagulation 610 $aRuta chalepensis 610 $aRutaceae 610 $achalepin 610 $achalepensin 610 $abioactivity 610 $abiosynthesis 610 $acoumarin3-carboxamides 610 $apyranocoumarins 610 $aanticancer activity 610 $aantibacterial activity 610 $afree radical polymerization 610 $aLED 610 $aphotocomposites 610 $adirect laser write 610 $aanalytical methods 610 $amodel plant 610 $anatural genetic variation 610 $anatural products 610 $asimple coumarins 610 $achalcocoumarin 610 $aMAO-B 610 $amolecular dynamics 610 $ain silico studies 610 $adye-sensitized solar cells 610 $acoumarin dyes 610 $athieno [3,2-b] thiophene 610 $acharge transfer 610 $aethynylaryl 610 $aesculetin 610 $aantiplatelet activity 610 $aimpedance aggregometry 610 $aCOX 610 $apolyphenols 610 $apyrazole 610 $aimidazole 610 $athiazole 610 $aoxazole 610 $atriazole 610 $athiadiazole 610 $acurcumin 610 $acurcumin-coumarin hybrids 610 $aneuroprotection 610 $amonoamine oxidase inhibition 610 $acholinesterase inhibition 610 $ascavenging activity 610 $aEscherichia coli 610 $abiotransformation 610 $aferulenol 610 $astructural annotation 610 $ain silico tools 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aMatos$b Maria Joa?o$4edt$01297538 702 $aMatos$b Maria Joa?o$4oth 906 $aBOOK 912 $a9910557577003321 996 $aCoumarin and Its Derivatives$93024513 997 $aUNINA