LEADER 04849nam 2201069z- 450 001 9910557576903321 005 20231214132957.0 035 $a(CKB)5400000000043880 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68663 035 $a(EXLCZ)995400000000043880 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNew Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (246 p.) 311 $a3-03936-100-7 311 $a3-03936-101-5 330 $aJöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer?Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications. 606 $aMedicine$2bicssc 606 $aNeurosciences$2bicssc 610 $abreast cancer 610 $adiffuse optical spectroscopy 610 $achemotherapy 610 $atime-domain spectroscopy 610 $anear-infrared spectroscopy 610 $aradiative transfer equation 610 $adiffusion equation 610 $abiological tissue 610 $atime-domain instruments 610 $alight propagation in tissue 610 $aoptical properties of tissue 610 $adiffuse optical tomography 610 $afluorescence diffuse optical tomography 610 $atime-resolved spectroscopy 610 $aNIRS 610 $adiffuse optics 610 $atime-domain 610 $atime-resolved 610 $abrain oxygenation 610 $atissue saturation 610 $ascattering 610 $aabsorption 610 $a3-hour sitting 610 $anear infrared time-resolved spectroscopy 610 $acompression stocking 610 $atissue oxygenation 610 $aextracellular water 610 $aintracellular water 610 $acircumference 610 $agastrocnemius 610 $aneonate 610 $avaginal delivery 610 $acerebral blood volume 610 $acerebral hemoglobin oxygen saturation 610 $anear-infrared time-resolved spectroscopy 610 $anear infrared spectroscopy 610 $aaging 610 $aprefrontal cortex 610 $aTRS 610 $amagnetic resonance imaging 610 $abrain atrophy 610 $aVSRAD 610 $aoptical pathlength 610 $ahemoglobin 610 $acognitive function 610 $atime-domain NIRS 610 $anull source-detector separation 610 $abrain 610 $anoninvasive 610 $asubcutaneous white adipose tissue 610 $atissue total hemoglobin 610 $adiffuse light 610 $ainverse problems 610 $aoptical tomography 610 $ainverse problem 610 $adatatypes 610 $adiffusion approximation 610 $ahighly forward scattering of photons 610 $adiffusion and delta-Eddington approximations 610 $acharacteristic length and time scales of photon transport 615 7$aMedicine 615 7$aNeurosciences 700 $aHoshi$b Yoko$4edt$01328681 702 $aHoshi$b Yoko$4oth 906 $aBOOK 912 $a9910557576903321 996 $aNew Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging$93038818 997 $aUNINA