LEADER 05204nam 2201321z- 450 001 9910557551003321 005 20231214133530.0 035 $a(CKB)5400000000044096 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69154 035 $a(EXLCZ)995400000000044096 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiomarkers of Environmental Toxicants 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (292 p.) 311 $a3-03936-736-6 311 $a3-03936-737-4 330 $aBiomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on ?Biomarkers of Environmental Toxicants?, review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies. 606 $aMedicine$2bicssc 610 $amanganese 610 $alead 610 $acadmium 610 $aarsenic 610 $ahair 610 $achildren 610 $aenvironment 610 $acarcinogen 610 $aDNA adducts 610 $abiomonitoring 610 $aformalin-fixed paraffin-embedded tissues 610 $abiomarker 610 $amass spectrometry 610 $ahuman biomonitoring 610 $aurine 610 $anon-occupational exposure 610 $aS-phenyl-mercapturic acid 610 $aHPLC-MS/MS 610 $aglycidol 610 $aHb adduct 610 $aN-(2.3-dihydroxypropyl)valine 610 $ain vivo 610 $acancer risk 610 $aUPLC/MS/MS 610 $aaristolochic acids 610 $afood contamination 610 $aenvironmental pollution 610 $aroot uptake 610 $aaristolochic acid nephropathy 610 $aBalkan endemic nephropathy 610 $achronic kidney disease 610 $atobacco smoke 610 $ahuman carcinogen 610 $abiomarkers 610 $aepitranscriptomics 610 $atRNA modifications 610 $astress response mechanisms 610 $acodon-biased translation 610 $aphthalate 610 $aDEHP 610 $ahuman exposure 610 $atoxicity 610 $areproductive 610 $aaccelerator mass spectrometry 610 $acavity ring down spectrophotometry 610 $aradiocarbon 610 $anaphthalene 610 $abenzo[a]pyrene 610 $acell turnover 610 $atriclocarban 610 $ametastasis 610 $ahaemoglobin 610 $aalbumin 610 $aprotein adducts 610 $aaldehydes 610 $agenotoxicity 610 $acancer 610 $adiseases 610 $aoxidative stress 610 $aexposure biomarkers 610 $ahigh-resolution mass spectrometry 610 $adata-dependent profiling 610 $aderivatization 610 $abiological fluids 610 $aisotope labeling 610 $aDNA lesion 610 $aDNA damage 610 $ashuttle vector technique 610 $areplication block 610 $amutagenicity 610 $amutational spectrum 610 $amutational signature 610 $aDNA repair 610 $aDNA adduct bypass 610 $asite-specific mutagenesis 610 $achemical exposome 610 $aenvironmental monitoring 610 $adisease 610 $abioinformatics 610 $agut microbiome 610 $achemical toxicity 615 7$aMedicine 700 $aLU$b Kun$4edt$0758171 702 $aTuresky$b Robert J$4edt 702 $aLU$b Kun$4oth 702 $aTuresky$b Robert J$4oth 906 $aBOOK 912 $a9910557551003321 996 $aBiomarkers of Environmental Toxicants$93035597 997 $aUNINA