LEADER 05289nam 2201369z- 450 001 9910557545203321 005 20231214133613.0 035 $a(CKB)5400000000044155 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76606 035 $a(EXLCZ)995400000000044155 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSphingolipids$eFrom Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (292 p.) 311 $a3-03943-957-X 311 $a3-03943-958-8 330 $aAlthough sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain?which contains the largest amounts of sphingolipids in the body?and first description in 1884 by J.L.W. Thudichum, sphingolipids have been overlooked for almost a century, perhaps due to their complexity and enigmatic nature. When sphingolipidoses were discovered, a series of inherited diseases caused by enzyme mutations involved in sphingolipid degradation returned to the limelight. The essential breakthrough came decades later, in the 1990s, with the discovery that sphingolipids were not just structural elements of cellular membranes but intra- and extracellular signaling molecules. It turned out that their lipid backbones, including ceramide and sphingosine-1-phosphate, had selective physiological functions. Thus, sphingolipids emerged as essential players in several pathologies including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The present volume reflects upon the unexpectedly eclectic functions of sphingolipids in health, disease, and therapy. This fascinating lipid class will continue to be the subject of up-and-coming future discoveries, especially with regard to new therapeutic strategies. 517 $aSphingolipids 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $aS1P receptor 610 $ainflammation 610 $aS1P transporter 610 $aspinster homolog 2 610 $abarrier dysfunction 610 $aanxiety 610 $adepression 610 $asphingolipids 610 $asphingomyelinase 610 $aceramidase 610 $aSmpd1 610 $aacid sphingomyelinase 610 $aforebrain 610 $adepressive-like behavior 610 $aanxiety-like behavior 610 $aceramide 610 $aceramides 610 $aceramidases 610 $aneurodegenerative diseases 610 $ainfectious diseases 610 $asphingosine 1-phoshate 610 $asphingosine 1-phosphate receptor 610 $aS1P1-5 610 $asphingosine 1-phosphate metabolism 610 $asphingosine 1-phosphate antagonistst/inhibitors 610 $asphingosine 1-phosphate signaling 610 $astroke 610 $amultiple sclerosis 610 $aneurodegeneration 610 $afingolimod 610 $aSphingosine-1-phosphate 610 $aobesity 610 $atype 2 diabetes 610 $ainsulin resistance 610 $apancreatic ? cell fate 610 $ahypothalamus 610 $asphingosine-1-phosphate 610 $aischemia/reperfusion 610 $acardioprotection 610 $avasoconstriction 610 $acoronary flow 610 $amyocardial function 610 $amyocardial infarct 610 $aalbumin 610 $atype 1 diabetes 610 $abeta-cells 610 $aislets 610 $ainsulin 610 $acytokines 610 $aS1P 610 $aanimal models 610 $acystic fibrosis 610 $aautophagy 610 $amyriocin 610 $aAspergillus fumigatus 610 $aCLN3 disease 610 $aCln3?ex7/8 mice 610 $aflupirtine 610 $aallyl carbamate derivative 610 $aapoptosis 610 $acancer 610 $agangliosides 610 $aimmunotherapy 610 $ametastasis 610 $aphenotype switching 610 $asphingosine 1-phosphate 610 $aSphingosine 1-phosphate (S1P) 610 $aS1P-lyase (SGPL1) 610 $atau 610 $acalcium 610 $ahistone acetylation 610 $ahippocampus 610 $acortex 610 $aastrocytes 610 $aneurons 610 $asphingosine kinase 610 $aG-protein-coupled receptors 610 $aG?q/11 610 $asphingosine kinase 1 610 $aSK1 610 $amicroRNA 610 $atranscription factor 610 $ahypoxia 610 $along non-coding RNA 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $avan Echten-Deckert$b Gerhild$4edt$01307154 702 $avan Echten-Deckert$b Gerhild$4oth 906 $aBOOK 912 $a9910557545203321 996 $aSphingolipids$93028702 997 $aUNINA