LEADER 00995cam0-2200337---450- 001 990004096920403321 005 20120530133857.0 035 $a000409692 035 $aFED01000409692 035 $a(Aleph)000409692FED01 035 $a000409692 100 $a19990604d1970----km-y0itay50------ba 101 1 $aita 102 $aIT 105 $ay-------00-y- 200 1 $aDidattica psicologica$eapplicazione alla didattica della psicologia di Jean Piaget$fHans Aebli$gpresentazione di Roberto Giannarelli 205 $a9. ristampa 210 $aFirenze$cGiunti-Barbera$d1970 215 $a198 p.$d21 cm 225 1 $aCollezione psicologica 610 0 $aPsicologia educativa 676 $a158 700 1$aAebli,$bHans$066517 702 1$aGiannarelli,$bRoberto 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004096920403321 952 $aP.1 PEP 89 A$bIst. fil. teor. 3042$fFLFBC 959 $aFLFBC 996 $aDidattica psicologica$9162312 997 $aUNINA LEADER 04039nam 2200469z- 450 001 9910557533303321 005 20211118 035 $a(CKB)5400000000044245 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73720 035 $a(oapen)doab73720 035 $a(EXLCZ)995400000000044245 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTesticular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function 210 $cFrontiers Media SA$d2020 215 $a1 online resource (132 p.) 311 08$a2-88963-568-6 330 $aTesticular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as infertility, hypogonadism, metabolic syndrome, osteoporosis, sexual disorders, depressed mood, and in general impaired quality of life. This aspect is the most serious and potentially life threatening effect in TGCT survivors. Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life. The objective of this Research Topic is to group a collection of articles focused on new and more recent insights about TGCT. 517 $aTesticular Cancer 606 $aEndocrinology$2bicssc 606 $aMedicine and Nursing$2bicssc 610 $acancer treatment 610 $agenetics 610 $amale infertility 610 $asexual function 610 $atestis cancer 615 7$aEndocrinology 615 7$aMedicine and Nursing 700 $aGarolla$b Andrea$4edt$01304436 702 $aDe Giorgi$b Ugo$4edt 702 $aMilardi$b Domenico$4edt 702 $aGarolla$b Andrea$4oth 702 $aDe Giorgi$b Ugo$4oth 702 $aMilardi$b Domenico$4oth 906 $aBOOK 912 $a9910557533303321 996 $aTesticular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function$93027407 997 $aUNINA