LEADER 05488nam 2201393z- 450 001 9910557527603321 005 20231214133331.0 035 $a(CKB)5400000000044302 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76325 035 $a(EXLCZ)995400000000044302 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPlasma in Cancer Treatment 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (358 p.) 311 $a3-0365-1209-8 311 $a3-0365-1208-X 330 $aIn the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments?such as immunotherapy?to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP?such as 3D in vitro, in ovo, and in vivo models and in silico approaches?as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling. 606 $aMedicine$2bicssc 610 $acell adhesion 610 $aplasma medicine 610 $aoncology 610 $acold atmospheric plasma 610 $aselectivity 610 $aplasma-treated liquid 610 $adielectric barrier discharge 610 $apancreatic cancer 610 $apancreatic stellate cells 610 $aimmunogenic cell death 610 $adendritic cells 610 $acell communication 610 $aextracellular matrix (ECM) 610 $areactive oxygen and nitrogen species (ROS) 610 $atumour microenvironment (TME) 610 $aextracellular vesicles 610 $acommunication junctions 610 $athree-dimensional in vitro culture models 610 $aapoptosis 610 $abreast cancer 610 $agenome-wide expression 610 $areactive oxygen species 610 $aanticancer drugs 610 $ascreening 610 $atumor spheroids 610 $acombination therapy 610 $akINPen 610 $areactive oxygen and nitrogen species 610 $aROS 610 $acancer 610 $anon-thermal atmospheric pressure plasma (NTP) 610 $aindirect treatment 610 $aplasma-treated phosphate-buffered saline 610 $aelectroporation 610 $aelectric pulses 610 $apulsed electric field amplitude 610 $amelanoma 610 $along-lived reactive species 610 $abone cancer 610 $aosteosarcoma 610 $areactive species 610 $aplasma-activated liquid 610 $aRinger's saline 610 $aorganotypic model 610 $anonthermal biocompatible plasma 610 $asoft jet plasma 610 $ahuman glioblastoma 610 $ap38/MAPK pathway 610 $atissue penetration 610 $anon-thermal plasma 610 $anon-invasive plasma treatment (NIPP) 610 $acervical intraepithelial neoplasia (CIN) 610 $aRaman imaging 610 $aRaman microspectroscopy 610 $aPlasma lipid interactions 610 $acold physical plasma 610 $aradiation therapy 610 $aradio-frequency discharge 610 $aPARP-inhibitor 610 $aolaparib 610 $aDNA-damage 610 $agold quantum dots 610 $aplasma 610 $ananomaterials 610 $acellular uptake 610 $ainvasiveness 610 $acold atmospheric pressure plasma 610 $aplasma-activated Ringer's lactate solution 610 $aovarian cancer 610 $acytotoxicity 610 $aplasma-activated liquids 610 $amulticellular tumor spheroids 610 $along-lived reactive oxygen and nitrogen species 610 $ahigh frequency electrosurgery 610 $aplasma treatment 610 $acold atmospheric plasma (CAP) 610 $afree radicals 610 $acancer selectivity 610 $acervical cancer treatment 610 $acervical intraepithelial neoplasia 610 $acholangiocarcinoma 610 $acold plasma 610 $ainnovative therapy 610 $atumor cells 610 $amacrophages 610 $aplasma selectivity 610 $aplasma jet 615 7$aMedicine 700 $aBogaerts$b Annemie$4edt$01312704 702 $aPrivat-Maldonado$b Angela$4edt 702 $aBogaerts$b Annemie$4oth 702 $aPrivat-Maldonado$b Angela$4oth 906 $aBOOK 912 $a9910557527603321 996 $aPlasma in Cancer Treatment$93030934 997 $aUNINA