LEADER 06848nam 2201225z- 450 001 9910557526003321 005 20210501 035 $a(CKB)5400000000044318 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68654 035 $a(oapen)doab68654 035 $a(EXLCZ)995400000000044318 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCrosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (320 p.) 311 08$a3-03936-330-1 311 08$a3-03936-331-X 330 $aMicroRNAs (miRNAs) are small noncoding RNAs that are 19-24 nucleotides in length, following maturation. Recent evidence has demonstrated their key role as post-transcriptional regulators of gene expression through the binding of specific sequences within target messenger RNA (mRNA). miRNAs are involved in the synthesis of a very large number of proteins, and it is speculated that they could regulate up to 30% of the human genome. They control virtually every cellular process and are essential for animal development, cell differentiation, and homeostasis. Altered miRNA expression has been linked to such pathological events as inflammatory, degenerative, or autoimmune processes and have been associated with several diseases, including cancer, cardiovascular diseases, diabetes mellitus, and rheumatic and neurological disorders. Recently, miRNAs have been found in many different biological fluids, and this observation suggests the potential of miRNAs as new candidate biomarkers for diagnosis, classification, prognosis, and responsiveness in the treatment of different pathological conditions. Furthermore, the development of therapeutic strategies that involve either restoring or repressing miRNAs expression and activity has attracted much attention. Significant progress has been made in the systems for delivery of miRNAs, even if substantial improvements in this area are still necessary. Although they have been extensively studied, a number of interesting questions regarding the physiological and pathological role of miRNAs have been postulated, and their potential diagnostic and therapeutic role remain yet unanswered. Reactive oxygen species (ROS) are free radical-containing oxygen molecules derived from cellular oxidative metabolism, including enzyme activities and mitochondrial respiration, and play a pivotal role in many cellular functions. Whereas ROS are essential for normal cellular processes, their aberrant production, or failure of the capacity to scavenge excessive ROS, induces an altered redox status with excessive synthesis of free radicals, leading to an imbalance in the redox environment of the cell. The loss of normal ROS levels causes lipid, protein, and DNA damage, which contribute to the development of various pathologies including neurological disorders, rheumatic and cardiovascular diseases, diabetes, and cancer. Increasing evidence highlights that there is crosstalk between miRNAs and components of redox signaling, even if this complex and the characteristics of mutual interaction need to be amply elucidated. Hence, both miRNAs and oxidative stress are involved in the multifactorial development and progression of acute and chronic diseases by influencing numerous signaling and metabolic pathways. The Special Issue entitled "Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology" of the International Journal of Molecular Sciences includes original articles and reviews that provide new insights into the interaction between miRNAs and oxidative stress under normal and pathological conditions which can assist in the development of new therapeutic strategies. Finally, I would like to thank all the authors for their excellent contribution. I hope this Special Issue will provide readers with updated knowledge about the role of miRNAs and oxidative stress in physiology and pathology. 606 $aMedicine and Nursing$2bicssc 610 $aacute myocardial infarction 610 $aALS 610 $aAlzheimer's disease 610 $aantioxidants 610 $aantisense oligonucleotide 610 $aapoptosis 610 $aASH 610 $aautophagy 610 $abeta cells 610 $abreast cancer 610 $acancer 610 $achemoresistance 610 $aclinical trial 610 $across-talk 610 $adiabetes 610 $aendometriosis 610 $aendometriosis-associated ovarian cancer 610 $aepithelial-to-mesenchymal transition 610 $aHBV 610 $aHCC 610 $aHCV 610 $ahigh-grade serous ovarian cancer 610 $aHuntington's disease 610 $ahypoxia 610 $aliver cancer 610 $along noncoding RNA 610 $ametabolism 610 $amicroRNA 610 $aMicroRNA 610 $aMicroRNA (miRNA) 610 $amicroRNAs 610 $amiR-27a-5p 610 $amiR526b 610 $amiR655 610 $amiRNA 610 $amiRNAs 610 $amitochondrial dysfunction 610 $an/a 610 $aNAFLD 610 $aNASH 610 $aneurodegeneration 610 $aNF-?B 610 $anitrosative stress. exosome 610 $anoncoding RNA 610 $anucleic acid medicine 610 $aosteoarthritis 610 $aoxidative stress 610 $apancreatic cancer 610 $aParkinson's disease 610 $aphysiology 610 $areactive oxygen species 610 $areactive oxygen species (ROS) 610 $aredox signaling 610 $aresistin 610 $aROS 610 $asignal transduction 610 $asiRNA 610 $asuperoxide (SO) 610 $asynovial fibroblasts 610 $asynovitis 610 $asystemic lupus erythematosus 610 $atherapeutic resistance 610 $atherapeutic target 610 $atherapeutic tolerance 610 $aThioredoxin Reductase 1 (TXNRD1) 610 $athyroid hormone 610 $atranslation regulation 610 $avisfatin 615 7$aMedicine and Nursing 700 $aFioravanti$b Antonella$4edt$01314821 702 $aDotta$b Francesco$4edt 702 $aGiordano$b Antonio$4edt 702 $aPirtoli$b Luigi$4edt 702 $aFioravanti$b Antonella$4oth 702 $aDotta$b Francesco$4oth 702 $aGiordano$b Antonio$4oth 702 $aPirtoli$b Luigi$4oth 906 $aBOOK 912 $a9910557526003321 996 $aCrosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology$93032010 997 $aUNINA