LEADER 06275nam 2201777z- 450 001 9910557519503321 005 20231214133221.0 035 $a(CKB)5400000000044384 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77009 035 $a(EXLCZ)995400000000044384 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAppetite and Satiety Control-Gut Mechanisms 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (454 p.) 311 $a3-0365-2348-0 311 $a3-0365-2347-2 330 $aThe prevalence of obesity and its comorbidities, particularly type 2 diabetes, cardiovascular and hepatic disease and certain cancers, continues to rise worldwide. Paradoxically, despite an increasingly obesogenic environment, particularly in Western societies, undernutrition is also extremely common. The application of novel, sophisticated techniques, particularly related to imaging and molecular biology, has substantially advanced our understanding of the mechanisms controlling appetite and energy intake. This has led to a redefinition of many concepts, including the relative importance of central versus peripheral mechanisms, recognising that the gastrointestinal (GI) tract, particularly gut hormones, plays a critical role. Given the major advance in knowledge in the field, this Special Issue provides a comprehensive overview of the GI mechanisms underlying the regulation of appetite and energy intake, as a series of definitive reviews by international authorities. The reviews address gut-related mechanisms, including nutrient sensing, gut hormones and GI motility, gut-brain communication, including the roles of the vagus and the modulation of reward perception, the roles of diet and the microbiota, as well as the abnormalities associated with eating disorders, specifically obesity and anorexia of ageing, and the beneficial effects of bariatric surgery. The reviews cover both preclinical research and studies in humans, and are complemented by a number of important original papers. 606 $aMedicine$2bicssc 610 $alixisenatide 610 $aintragastric meal retention 610 $aenergy intake 610 $atype 2 diabetes 610 $aobesity 610 $aamino acid 610 $aisoleucine 610 $achronic supplementation 610 $aenergy expenditure 610 $aoral glucose tolerance test 610 $aglycaemic control 610 $agastric emptying breath test 610 $aendocannabinoid 610 $acannabinoid CB1 receptor 610 $agut-brain 610 $aintestine 610 $awestern diet 610 $apreference 610 $awhey protein 610 $agastric emptying 610 $aappetite 610 $alifecourse 610 $agut hormones 610 $ahunger 610 $aprotein 610 $aTAS2R5 610 $aTAS2R39 610 $aTAS2R14 610 $aagonist 610 $afood intake 610 $aGLP1 610 $aCCK 610 $aPYY 610 $aminiature pig 610 $apig model 610 $afunctional brain imaging 610 $amolecular imaging 610 $avagal afferents 610 $asingle fiber recording 610 $ainsulin resistance 610 $aGLP-1r 610 $agastric barostat 610 $ascintigraphy 610 $ameal ingestion 610 $apostprandial responses 610 $ahedonic sensations 610 $ahomeostatic sensations 610 $aabdominal wall activity 610 $aabdominal distension 610 $ataste 610 $afat 610 $acarbohydrate 610 $abariatric surgery 610 $aGLP-1 610 $aghrelin 610 $aRoux-en-Y gastric bypass 610 $agastric band 610 $asleeve gastrectomy 610 $acircadian 610 $agastrointestinal tract 610 $aenteroendocrine cells 610 $achemosensory 610 $aGIP 610 $anutrients 610 $ahormones 610 $afood ingestion 610 $adigestion 610 $asatiety 610 $adigestive well-being 610 $afunctional gastrointestinal disorders 610 $apostprandial symptoms 610 $abrainstem 610 $avagus 610 $afeeding 610 $agastrointestinal 610 $acue reactivity 610 $ameal anticipation 610 $amotivation 610 $anutrient preference 610 $aflavor 610 $aaversion 610 $abile acids 610 $aTGR-5 610 $aFXR 610 $agastrointestinal hormones 610 $abody weight 610 $agastric accommodation 610 $asatiation 610 $aCB1 receptor 610 $agut-brain 610 $areward 610 $aaging 610 $awhey 610 $aanorexia 610 $asupplements 610 $asarcopenia 610 $anutrient sensing 610 $aenteroendocrine cells (EECs) 610 $aappetite regulation 610 $aG-protein coupled receptors (GPCRs) 610 $abitter substances 610 $agastric motor function 610 $apostprandial blood glucose 610 $apreclinical studies 610 $ahuman studies 610 $atexture 610 $aoro-sensory exposure 610 $asensory science 610 $acephalic responses 610 $abrain areas 610 $abrain stem 610 $aweight management 610 $aintestinal brake 610 $aduodenal jejunal and ileal brake 610 $atastants 610 $acircadian clock 610 $agastric bypass surgery 610 $amicrobiome 610 $ahypothalamus 615 7$aMedicine 700 $aFeinle-Bisset$b Christine$4edt$01293627 702 $aHorowitz$b Michael$4edt 702 $aFeinle-Bisset$b Christine$4oth 702 $aHorowitz$b Michael$4oth 906 $aBOOK 912 $a9910557519503321 996 $aAppetite and Satiety Control-Gut Mechanisms$93022678 997 $aUNINA