LEADER 06550nam 2201693z- 450 001 9910557505903321 005 20231214132856.0 035 $a(CKB)5400000000044497 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68521 035 $a(EXLCZ)995400000000044497 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFlavonoids and Their Disease Prevention and Treatment Potential 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (346 p.) 311 $a3-0365-0000-6 311 $a3-0365-0001-4 330 $aFlavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6?C3?C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment. 606 $aHumanities$2bicssc 606 $aSocial interaction$2bicssc 610 $aluteolin 610 $aapigenin 610 $abacoside A 610 $abacopaside I 610 $avasorelaxation 610 $aisorhamnetin 610 $aflavonoid 610 $abacterial sepsis 610 $atoll-like receptor 4 610 $ainflammation 610 $acitrus flavonoids 610 $aneohesperidin 610 $aanti-aging activity 610 $achronological lifespan 610 $asynergistic effect 610 $aclinical trials 610 $anatural products 610 $ahyperalgesia 610 $aallodynia 610 $aanalgesia 610 $ahypersensitivity 610 $acytokines 610 $aNF-kB 610 $adefatted pitaya seed 610 $aextraction 610 $aphenolic content 610 $aflavonoid content 610 $aantioxidant activity 610 $aresponse surface methodology 610 $aflavonoids 610 $aaglycons 610 $aglycosides 610 $aIL-1? 610 $aTNF-? 610 $aIL-6 610 $aIL-8 610 $apro-inflammatory cytokines 610 $aAcer okamotoanum 610 $aafzelin 610 $aisoquercitrin 610 $aobesity 610 $aquercitrin 610 $aaspirin 610 $acancer prevention 610 $ahydroxybenzoic acids 610 $acell cycle 610 $aCDKs 610 $acolorectal cancer 610 $ainfectious diseases 610 $aamoebiasis 610 $aMexican oregano 610 $abioguided isolation 610 $aantiprotozoal agents 610 $aflavones 610 $acancer 610 $amicrobiome 610 $amolecular mechanisms 610 $agene and protein regulatory networks 610 $amacrophages 610 $aNF-?B 610 $aIKK?, inflammatory cytokines 610 $aapoptosis 610 $afoods for health 610 $atangeretin 610 $acancer stem cells 610 $aStat3 610 $acitrus 610 $aCD44+/CD24? 610 $aphytochemicals 610 $aflavonoids and their derivatives 610 $aphytomedicine 610 $aCOVID-19 610 $aSARS-COV-2 610 $asmart nanoparticles 610 $anon-flavonoids 610 $amembrane PUFAs profile 610 $acell morphology 610 $ahuman colon cancer cells 610 $acranberry 610 $aurinary tract infections 610 $aUTIs 610 $auropathogenic Escherichia coli 610 $aUPEC 610 $aflavan-3-ols 610 $aA-type proanthocyanidins 610 $aphenolic metabolites 610 $aantiadhesive activity 610 $aprobiotics 610 $aanthocyanin 610 $atobacco-specific nitrosamine 610 $acarcinogenesis 610 $acell proliferation 610 $acancer chemoprevention 610 $alung cancer 610 $achalcones 610 $aDNA damage 610 $aanticancer activity 610 $acanine cancer cell lines 610 $aangiogenesis 610 $ain-vivo angiogenesis 610 $aCAM assay 610 $aSAR 610 $acognition 610 $apassive avoidance test 610 $amemory extinction 610 $amice 610 $amicroglia 610 $aneuroprotection 610 $ablack rice cyanidin-3-O-glucoside 610 $awood sterols 610 $adyslipidemia 610 $aCVD 615 7$aHumanities 615 7$aSocial interaction 700 $aRupasinghe$b H.P. Vasantha$4edt$01283178 702 $aRupasinghe$b H.P. Vasantha$4oth 906 $aBOOK 912 $a9910557505903321 996 $aFlavonoids and Their Disease Prevention and Treatment Potential$93018931 997 $aUNINA