LEADER 05875nam 2201429z- 450 001 9910557504803321 005 20231214133353.0 035 $a(CKB)5400000000044508 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69087 035 $a(EXLCZ)995400000000044508 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntitumor and Anti-HIV Agents from Natural Products 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (338 p.) 311 $a3-03943-008-4 311 $a3-03943-009-2 330 $aCancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered. 606 $aResearch & information: general$2bicssc 610 $anatural phaeosphaeride A 610 $aantitumor activity 610 $ahuman tumor cell lines 610 $aHEF cell line 610 $aacute toxicity 610 $aaspidosperma-type 610 $amonoterpenoid indole alkaloids 610 $aantiproliferative activity 610 $atubulin inhibitor 610 $aBousigonia mekongensis 610 $aursolic acid 610 $aDOTA 610 $atriterpenoids 610 $acytotoxicity 610 $aditerpenoid alkaloids 610 $ahuman tumor cells 610 $alipojesaconitine 610 $adelcosine 610 $adelpheline 610 $akobusine 610 $apseudokobusine 610 $aBRAF inhibitor 610 $aMentha aquatica var. Kenting Water Mint 610 $aessential oil 610 $achemoprevention 610 $atwo-stage skin carcinogenesis 610 $amelanoma 610 $acurcumin analog 610 $aapoptosis 610 $aoxidative stress 610 $adrug?drug interaction 610 $atamoxifen 610 $ataxol 610 $acisplatin 610 $aArtemisia absinthium L. 610 $aantioxidants 610 $atotal phenolic content 610 $amelanoma and breast cancer cell line 610 $aHaCaT cells 610 $ainflammation 610 $abreast cancer 610 $acell cycle 610 $aflavonoids 610 $areactive oxygen species 610 $atumor suppression 610 $aantiretroviral agents 610 $aanti-HIV 610 $amarine metabolites 610 $anatural products 610 $adrug development 610 $aIvalin 610 $aCarpesium divaricatum 610 $ahepatocellular carcinoma 610 $amitochondria-mediated apoptosis 610 $aNF-?B 610 $aHernandia nymphaeifolia 610 $abutanolides 610 $alignan glycosides 610 $acoumarins 610 $aantiangiogenic 610 $acancer 610 $anatural agents 610 $achemistry 610 $amedicine 610 $acancer stem cell 610 $acervical cancer 610 $apterostilbene 610 $aresveratrol 610 $acaffeic acid 610 $acancer multidrug resistance 610 $aP-glycoprotein 610 $aphenolic acid 610 $aoxypeucedanin 610 $aAngelica dahurica 610 $aantiproliferation 610 $aG2/M phase cell cycle arrest 610 $ap53 610 $aSK-Hep-1 610 $ahepatoma cells 610 $aallyl isothiocyanate 610 $abenzyl isothiocyanate 610 $asulforaphane 610 $aphenethyl isothiocyanate 610 $abladder cancer 610 $aquercetin 610 $aoral squamous cell carcinoma cells 610 $ametastasis 610 $acell cycle arrest 610 $aepithelial-to-mesenchymal transition 610 $amatrix metalloproteinase 610 $atransforming growth factor-?1 610 $a?-lapachone 615 7$aResearch & information: general 700 $aNakagawa-Goto$b Kyoko$4edt$01322913 702 $aNakagawa-Goto$b Kyoko$4oth 906 $aBOOK 912 $a9910557504803321 996 $aAntitumor and Anti-HIV Agents from Natural Products$93035257 997 $aUNINA