LEADER 03959nam 2201081z- 450 001 9910557497703321 005 20231214133214.0 035 $a(CKB)5400000000042854 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76609 035 $a(EXLCZ)995400000000042854 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein-Ligand Interactions: Target Identification and Drug Discovery 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (184 p.) 311 $a3-0365-1050-8 311 $a3-0365-1051-6 330 $aBioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. 517 $aProtein?Ligand Interactions 517 $aProtein-Ligand Interactions 517 $aProtein?Ligand Interactions 606 $aResearch & information: general$2bicssc 606 $aChemistry$2bicssc 610 $aserum half-life extension 610 $afatty acid conjugation 610 $aFcRn-mediated recycling 610 $aserum albumin 610 $atranslocator protein (TSPO) 610 $aCoCl2 610 $amitochondrial membrane potential 610 $areactive oxygen species (ROS) 610 $acell viability 610 $acell death 610 $alung cancer cell line 610 $aacetylcholinesterase 610 $aamyloid beta aggregation 610 $aneuroprotection 610 $amolecular docking 610 $amulti-target drug 610 $astructure?activity relationship 610 $abrassicasterol 610 $aphytosterols 610 $aHSV 610 $aMycobacterium tuberculosis 610 $aHSV-1 DNA polymerase 610 $aHSV-1 TK 610 $ahuman CDK2 610 $aACE 610 $aUDP-galactopyranose mutase 610 $aheat shock protein 70 610 $aHsp70 610 $apiperine 610 $afluorescence spectroscopy 610 $amolecular dynamics 610 $amolecular biophysics 610 $aGADD45? 610 $aMKK7 610 $amultiple myeloma 610 $aprotein-ligand interaction 610 $aSTD-NMR 610 $asigma receptors 610 $asigma ligands 610 $acancer 610 $aSIGMAR1 610 $aPGRMC1 610 $aTMEM97 610 $aNCI60 COMPARE analysis 610 $amembrane 610 $alipid-protein interaction 610 $alipid signalling 610 $akinase regulation 610 $aphosphatidylinositols 610 $amolecular docking simulation 610 $atarget identification 610 $asmall-molecule derivatives of salicylanilide 610 $adrug discovery 610 $adrug development 610 $athyroid diseases 610 $aendocrine disruptor compound 610 $ahuman umbilical artery 610 $avascular homeostasis 615 7$aResearch & information: general 615 7$aChemistry 700 $aAltieri$b Fabio$4edt$01311497 702 $aAltieri$b Fabio$4oth 906 $aBOOK 912 $a9910557497703321 996 $aProtein-Ligand Interactions: Target Identification and Drug Discovery$93030346 997 $aUNINA