LEADER 03978nam 2201093z- 450 001 9910557497703321 005 20220111 035 $a(CKB)5400000000042854 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76609 035 $a(oapen)doab76609 035 $a(EXLCZ)995400000000042854 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aProtein-Ligand Interactions: Target Identification and Drug Discovery 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (184 p.) 311 08$a3-0365-1050-8 311 08$a3-0365-1051-6 330 $aBioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. 517 $aProtein?Ligand Interactions 517 $aProtein-Ligand Interactions 517 $aProtein?Ligand Interactions 606 $aChemistry$2bicssc 606 $aResearch and information: general$2bicssc 610 $aACE 610 $aacetylcholinesterase 610 $aamyloid beta aggregation 610 $abrassicasterol 610 $acancer 610 $acell death 610 $acell viability 610 $aCoCl2 610 $adrug development 610 $adrug discovery 610 $aendocrine disruptor compound 610 $afatty acid conjugation 610 $aFcRn-mediated recycling 610 $afluorescence spectroscopy 610 $aGADD45? 610 $aheat shock protein 70 610 $aHsp70 610 $aHSV 610 $aHSV-1 DNA polymerase 610 $aHSV-1 TK 610 $ahuman CDK2 610 $ahuman umbilical artery 610 $akinase regulation 610 $alipid signalling 610 $alipid-protein interaction 610 $alung cancer cell line 610 $amembrane 610 $amitochondrial membrane potential 610 $aMKK7 610 $amolecular biophysics 610 $amolecular docking 610 $amolecular docking simulation 610 $amolecular dynamics 610 $amulti-target drug 610 $amultiple myeloma 610 $aMycobacterium tuberculosis 610 $aNCI60 COMPARE analysis 610 $aneuroprotection 610 $aPGRMC1 610 $aphosphatidylinositols 610 $aphytosterols 610 $apiperine 610 $aprotein-ligand interaction 610 $areactive oxygen species (ROS) 610 $aserum albumin 610 $aserum half-life extension 610 $asigma ligands 610 $asigma receptors 610 $aSIGMAR1 610 $asmall-molecule derivatives of salicylanilide 610 $aSTD-NMR 610 $astructure-activity relationship 610 $atarget identification 610 $athyroid diseases 610 $aTMEM97 610 $atranslocator protein (TSPO) 610 $aUDP-galactopyranose mutase 610 $avascular homeostasis 615 7$aChemistry 615 7$aResearch and information: general 700 $aAltieri$b Fabio$4edt$01311497 702 $aAltieri$b Fabio$4oth 906 $aBOOK 912 $a9910557497703321 996 $aProtein-Ligand Interactions: Target Identification and Drug Discovery$93030346 997 $aUNINA