LEADER 04308nam 2200925z- 450 001 9910557463003321 005 20220111 035 $a(CKB)5400000000043169 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76840 035 $a(oapen)doab76840 035 $a(EXLCZ)995400000000043169 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (5793 p.) 311 08$a3-0365-1506-2 311 08$a3-0365-1505-4 330 $aThe sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of age-related and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs. 606 $aMedicine and Nursing$2bicssc 610 $aadenosine A1 receptor 610 $aadjunctive therapy 610 $aage-related hearing loss 610 $aaging 610 $aastrocytes 610 $aauditory brainstem 610 $abrain-derived neurotrophic factor 610 $aCCG-4986 610 $achronic oral treatment 610 $acircadian dysregulation 610 $aclock genes 610 $acochlear nucleus 610 $acochlear rescue 610 $ad-galactose 610 $adeafness 610 $adevelopment 610 $agap junctions 610 $ahearing loss 610 $ahearing protection 610 $ahigh-fat diet 610 $ahyperbaric oxygenation 610 $ahypoxic 610 $ainferior colliculus 610 $ainner ear 610 $aintratympanic drug delivery 610 $aKCNQ4 activator 610 $alateral superior olive 610 $amicroRNAs 610 $amitochondria dysfunction 610 $amouse model 610 $an/a 610 $aneuroplasticity 610 $anoise-induced cochlear injury 610 $anoise-induced hearing loss 610 $anonsyndromic hearing loss 610 $aotoferlin 610 $aotoprotection 610 $apotassium 610 $apotassium voltage-gated channel subfamily q member 4 610 $areactive oxygen species 610 $aregulator of G protein signalling 4 610 $aselegiline 610 $asensorineural hearing loss 610 $asensory hair cells 610 $aspontaneous activity 610 $asynaptic ribbons 610 $aTrkB 610 $avoltage-activated calcium channel 1.3 610 $azebrafish 615 7$aMedicine and Nursing 700 $aVlajkovic$b Srdjan M$4edt$01311345 702 $aVlajkovic$b Srdjan M$4oth 906 $aBOOK 912 $a9910557463003321 996 $aMolecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics$93030272 997 $aUNINA