LEADER 02769nam 22005053a 450 001 9910557460503321 005 20250203235434.0 010 $a9783038975717 010 $a3038975710 024 8 $a10.3390/books978-3-03897-571-7 035 $a(CKB)4100000010106508 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/47256 035 $a(ScCtBLL)4192f3f3-12cd-48d7-86fd-709f95c89ffe 035 $a(OCoLC)1163844667 035 $a(oapen)doab47256 035 $a(EXLCZ)994100000010106508 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aExtracellular Matrix in Development and Disease$fJulia Oxford 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (356 p.) 311 08$a9783038975700 311 08$a3038975702 330 $aThe extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection. 606 $aBiology, life sciences$2bicssc 610 $atissue engineering 610 $aembryonic development 610 $abiofilm 610 $acollagen 610 $afibrosis 610 $aextracellular matrix 610 $adegenerative disease 615 7$aBiology, life sciences 700 $aOxford$b Julia$01787742 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910557460503321 996 $aExtracellular Matrix in Development and Disease$94321376 997 $aUNINA