LEADER 04423nam 2201093z- 450 001 9910557430503321 005 20231214133052.0 035 $a(CKB)5400000000043418 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68973 035 $a(EXLCZ)995400000000043418 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPhysiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (236 p.) 311 $a3-03936-282-8 311 $a3-03936-283-6 330 $aROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms? adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging. 517 $aPhysiological and Pathological Role of ROS 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $aCTCL 610 $aapoptosis 610 $acell viability 610 $ac-FLIP 610 $aXIAP 610 $aartemisinin 610 $aSH-SY5Y cells 610 $ahippocampal neurons 610 $aH2O2 610 $aAMPK pathway 610 $aatherosclerosis 610 $asphingomyelin synthase 2 610 $aendothelial dysfunction 610 $aendoplasmic reticulum stress 610 $a?-catenin 610 $ainsulin resistance 610 $acancer 610 $acardiovascular disease 610 $aneurodegenerative disorders 610 $aexercise 610 $amitochondria 610 $aoxidative stress 610 $aPGC-1 610 $aNrf2 610 $aUCPs 610 $aROS 610 $alight 610 $aDNA damage 610 $aevolution 610 $aD-box 610 $acavefish 610 $aSpalax 610 $atrimethylamine N-oxide 610 $acardiomyocytes 610 $acardiotoxicity 610 $amitochondrial membrane potential 610 $aCORM-2 610 $aNADPH oxidase 610 $aAP-1 610 $aHO-1 610 $aRenal cell carcinoma (RCC) 610 $areactive oxygen species (ROS) 610 $aglutathione (GSH) metabolism 610 $acancer therapy 610 $aclear cell RCC 610 $apapillary RCC 610 $achromophobe RCC 610 $asarcopenia 610 $areactive oxygen species 610 $aredox signaling 610 $aantioxidant supplementation 610 $aprotein aggregation 610 $aredox 610 $aproteinopathy 610 $aperoxiredoxins 610 $atumorigenesis 610 $aROS scavengers 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aDi Meo$b Sergio$4edt$01314049 702 $aVenditti$b Paola$4edt 702 $aNapolitano$b Gaetana$4edt 702 $aDi Meo$b Sergio$4oth 702 $aVenditti$b Paola$4oth 702 $aNapolitano$b Gaetana$4oth 906 $aBOOK 912 $a9910557430503321 996 $aPhysiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment$93031626 997 $aUNINA