LEADER 03714nam 2201033z- 450 001 9910557414003321 005 20231214133342.0 035 $a(CKB)5400000000043555 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68513 035 $a(EXLCZ)995400000000043555 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFrom Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (188 p.) 311 $a3-0365-0112-6 311 $a3-0365-0113-4 330 $aThis Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage?the first step in carcinogenesis?must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools. 606 $aHumanities$2bicssc 606 $aSocial interaction$2bicssc 610 $agraphene oxide 610 $areduced graphene oxide 610 $amicronucleus 610 $aoxidative stress 610 $asafer-by-design 610 $atungsten 610 $ananoparticles 610 $atritiated particles 610 $ain vitro testing 610 $acytotoxicity 610 $amicronuclei formation 610 $aDNA damage 610 $aepigenetics 610 $aDNA methylation 610 $aBEAS-2B cells. 610 $apolystyrene nanoparticles 610 $ananoplastics 610 $agenotoxicity 610 $aHs27 human fibroblasts 610 $acomet assay 610 $aFPG enzyme 610 $aTiO2NP 610 $aSiO2NP 610 $aZnONP 610 $aCeO2NP 610 $aAgNP 610 $amulti-walled carbon nanotubes (MWCNT) 610 $atitanium dioxide nanoparticles 610 $alincomycin 610 $ahuman amniotic cells 610 $ain vitro genotoxicity 610 $aapoptosis 610 $ananotoxicology 610 $ametal oxides 610 $ahigh throughput screening 610 $amicronucleus assay 610 $ananomaterial 610 $aaluminum 610 $aoral route 610 $agut 610 $aliver 610 $aV79 cells 610 $aHprt 610 $aadvanced in vitro model 610 $ahepatotoxicity 610 $aliver spheroids 610 $a3D culture 610 $aHepG2 610 $anongenotoxic silver nanoparticles 610 $agenotoxic 610 $acytotoxic 610 $aantioxidant activity 610 $asilver ions 610 $aAllium cepa 610 $ametal/coating agent ratio 615 7$aHumanities 615 7$aSocial interaction 700 $aFESSARD$b Vale?rie$4edt$01297531 702 $aNesslany$b Fabrice$4edt 702 $aFESSARD$b Vale?rie$4oth 702 $aNesslany$b Fabrice$4oth 906 $aBOOK 912 $a9910557414003321 996 $aFrom Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials$93024504 997 $aUNINA