LEADER 04109nam 2201057z- 450 001 9910557409503321 005 20210501 035 $a(CKB)5400000000043581 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69062 035 $a(oapen)doab69062 035 $a(EXLCZ)995400000000043581 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMatrix Metalloproteinases in Health and Disease 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (196 p.) 311 08$a3-03943-052-1 311 08$a3-03943-053-X 330 $aMatrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual's disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems. 606 $aHumanities$2bicssc 606 $aSocial interaction$2bicssc 610 $aacute kidney injury 610 $aadhesion 610 $aapoptosis 610 $aarterial aneurysms 610 $aautoantibodies 610 $abiomarkers 610 $aCaco-2 610 $aCD147 610 $acGMP 610 $achronic kidney disease 610 $aCKD 610 $acollagenases 610 $aCrohn's disease 610 $adental caries 610 $adialysis 610 $adisease 610 $aeGFR 610 $aeNOS 610 $afibrosis 610 $agenetic association 610 $ahealth 610 $ahigh-flux dialysis 610 $ahypersensitivity pneumonitis 610 $ainflammation 610 $ainflammatory bowel disease 610 $aiNOS 610 $aintegrin ?M?2 610 $aischemia/reperfusion 610 $akidney transplantation 610 $aleukocytes 610 $aMac-1 610 $aMAPKs 610 $amatrix metalloproteinase 610 $amatrix metalloproteinase-7 610 $amatrix metalloproteinase-9 610 $amatrix metalloproteinases 610 $ametalloproteinases 610 $aMMP-9 610 $aMMP1 610 $aMMP2 610 $aMMPs 610 $amouth 610 $aNGAL 610 $aNO 610 $aon-line hemodiafiltration 610 $aPAD. 610 $apatients 610 $aperiodontitis 610 $aperipheral vascular disease 610 $aplatelets 610 $aproteinuria 610 $aRECK 610 $arenal replacement therapy 610 $aSNPs 610 $astatins 610 $asynthetic inhibitors 610 $aTIMP 610 $aTIMPs 615 7$aHumanities 615 7$aSocial interaction 700 $aSerra$b Raffaele$4edt$01311350 702 $aSerra$b Raffaele$4oth 906 $aBOOK 912 $a9910557409503321 996 $aMatrix Metalloproteinases in Health and Disease$93030277 997 $aUNINA