LEADER 08337nam 2202725z- 450 001 9910557404603321 005 20210501 035 $a(CKB)5400000000043630 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69315 035 $a(oapen)doab69315 035 $a(EXLCZ)995400000000043630 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Tight Junction and Its Proteins$eMore Than Just a Barrier 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (432 p.) 311 08$a3-03943-300-8 311 08$a3-03943-301-6 330 $aFor a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer. 517 $aTight Junction and Its Proteins 606 $aMedicine$2bicssc 610 $aactomyosin 610 $aadherens junction 610 $aadherens junctions 610 $aaging 610 $aAMP-activated protein kinase (AMPK) 610 $aangubindin-1 610 $aangulin 610 $aanhidrosis 610 $aantibiotic-associated hemorrhagic colitis 610 $aantibody 610 $aantidiuretic hormone 610 $aapical junctional complex 610 $aapoptosis 610 $aaquaporin 610 $aarachnoid barrier 610 $aatopic dermatitis 610 $aatypical aPKC? 610 $abarrier formation 610 $abarrier function 610 $abiliary epithelial cells 610 $ablood-biliary barrier 610 $ablood-brain barrier 610 $ablood-brain barrier 610 $ablood-cerebrospinal fluid barrier 610 $abrain barriers 610 $acalcium permeability 610 $aCampylobacter jejuni 610 $acancer 610 $acaspase 610 $aCaSR 610 $aceliac disease 610 $acell growth 610 $acell polarity 610 $acell-cell contact 610 $acerebral cavernous malformation 610 $achemoresistance 610 $acholangiocellular carcinoma 610 $acholestasis 610 $achronic liver disease 610 $aclaudin 610 $aClaudin 610 $aclaudin 1 610 $aclaudin targeting 610 $aclaudin-1 610 $aclaudin-12 610 $aClaudin-14 610 $aclaudin-2 610 $aclaudin-5 610 $aClaudin-7 610 $aclaudins 610 $aClC-2 610 $aCLDN14 610 $aClostridium perfringens enterotoxin 610 $aClostridium perfringens iota-toxin 610 $aco-culture 610 $acochlear implantation 610 $acollecting duct 610 $acurcumin 610 $acytokines 610 $adisease 610 $adorsal root ganglion 610 $adrinking rate 610 $adrug development 610 $adrug discovery 610 $aendometrial cancer 610 $aendothelia 610 $aendothelial barrier 610 $aenterocyte 610 $aenteropathogenic E. coli (EPEC) 610 $aenvironmental sensors 610 $aepidermal barrier 610 $aepithelia 610 $aepithelial barrier 610 $aepithelial barrier dysfunction 610 $aepithelial fluid transport 610 $aepithelial sodium channel (ENaC), collecting duct cells 610 $aepithelial to mesenchymal transition 610 $aepithelium 610 $aEspF 610 $afibrosis 610 $agene transcription 610 $agland dysfunction 610 $aglia limitans 610 $ahearing loss 610 $aHELIX syndrome 610 $aHepatitis C Virus 610 $ahepatocellular carcinoma 610 $ahuman 610 $ahydrogen peroxide 610 $ahydrostatic pressure 610 $ahypermagnesemia 610 $ahypertrophy 610 $ahypokalemia 610 $aimmune cells 610 $ain silico 610 $ainflammation 610 $ainflammatory bowel disease 610 $ainterleukin 13 610 $aintestinal mucosa 610 $aintestine 610 $aion channel 610 $aion reabsorption 610 $aion transport 610 $aischemia 610 $ajunctional adhesion molecule 610 $akidney 610 $akidney stones 610 $aKlebsiella oxytoca 610 $alipolysis-stimulated lipoprotein receptor (LSR) 610 $aliver 610 $alung 610 $aMAGUK proteins 610 $aMDCK C7 cells 610 $aMEKK3 610 $amembrane proteins 610 $ametastasis 610 $amice 610 $amigration 610 $amolecular dynamics 610 $amonocytes 610 $amouse colon 610 $amucosal immunology 610 $amucus 610 $amutations 610 $aMz-ChA-1 cells 610 $anephropathy 610 $anerve injury 610 $aNES 610 $aneuropathic pain 610 $aneurovascular unit 610 $aNF?B 610 $aNHE2 610 $aNISCH syndrome 610 $aNLS 610 $aoccludin 610 $aorgan preservation 610 $aosmolality 610 $aosmoregulation 610 $aparacellular 610 $aparacellular barrier 610 $aparacellular channels and barriers 610 $aparacellular permeability 610 $aparacellular sodium transport 610 $aparacellular transport 610 $aparacellular water transport 610 $apathogens 610 $aPDZ domain 610 $apermeability 610 $aphosphatidylcholine 610 $aphosphorylation 610 $apolarity 610 $aproliferation 610 $aprotein domain 610 $aprotein interactions 610 $aprotein structure 610 $aproximal tubule 610 $aquercetin 610 $areconstructed human epidermis 610 $arepair 610 $aretinal pigment epithelium 610 $aretinopathy 610 $aRho 610 $aRhoA 610 $aROCK 610 $asensor 610 $asingle molecule localization microscopy 610 $askin 610 $asorting nexin 9 (SNX9) 610 $aSTAT3 610 $astem cell 610 $astimulated emission depletion 610 $astructured illumination microscopy 610 $asuper-resolution microscopy 610 $athick ascending limb 610 $atight epithelium 610 $atight junction 610 $atight junction assembly 610 $atight junctions 610 $atight junctions (TJ) 610 $atissue barrier 610 $aTNF 610 $atransepithelial electrical resistance (TER) 610 $atransplantation 610 $atricellular tight junction 610 $atricellular tight junctions 610 $atricellulin 610 $atumor 610 $atumor suppressor 610 $aUBE2Z 610 $aubiquitin 610 $avestibular function 610 $aviral entry 610 $aWNK4 610 $aZO-1 610 $aZO-2 610 $azonula occludens 615 7$aMedicine 700 $aFromm$b Michael$4edt$01287935 702 $aKrug$b Susanne M$4edt 702 $aFromm$b Michael$4oth 702 $aKrug$b Susanne M$4oth 906 $aBOOK 912 $a9910557404603321 996 $aThe Tight Junction and Its Proteins$93020581 997 $aUNINA