LEADER 04416nam 2200745z- 450 001 9910557382703321 005 20220111 035 $a(CKB)5400000000042072 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76942 035 $a(oapen)doab76942 035 $a(EXLCZ)995400000000042072 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCellular Senescence in Health, Disease and Aging: Blessing or Curse? 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (112 p.) 311 08$a3-0365-2175-5 311 08$a3-0365-2176-3 330 $aDear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems, occurring SC are usually detected and removed. If SC remain in the tissue expressing the SASP, this will cause not just a damaging local inflammation but can also induce remodeling and regeneration of the surrounding tissue as well as spreading of senescence. Old organisms show reduced regenerative potential and immune function which leads to accumulation of SC. Accordingly, accumulation of SC was observed in tissues of aged individuals, but importantly also in the context of age-related disorders, neurodegenerative, or cardiovascular diseases and others. Because of its detrimental effect of the surrounding tissue, accumulation of SC is not just a consequence, but can rather been understood as a major driver of aging. In line with this, recent studies described that removal of SC showed beneficial effects on healthspan and lifespan. This exciting research led to the discovery of "senolytics", drugs which can kill SC. Given the heterogeneity of cell types that show senescence-like phenotypes, including heart muscle and post-mitotic neuronal cells, further research is required to unravel the molecular background that renders a cell type vulnerable to senesce. Additionally, it will be important to understand how senescence is cell type-specifically induced and which molecules serve as drug targets to prevent senescence and its spreading, or actively kill SC. This special issue will shed light on the molecular pathways of CS and inflammaging and on possible strategies to interfere with these processes. Dr. Markus Riessland Guest Editor 517 $aCellular Senescence in Health, Disease and Aging 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $aAIM2 inflammasome 610 $aAlzheimer's disease 610 $aamyotrophic lateral sclerosis 610 $abiology of aging 610 $abrain 610 $acancer 610 $acell-cycle 610 $acellular senescence 610 $achemotherapy resistance 610 $aDNA damage 610 $ageroscience 610 $ahomeostasis 610 $ainflammation 610 $amelanoma 610 $amild cognitive impairment 610 $an/a 610 $aneurodegeneration 610 $aneuronal senescence 610 $apancreatic adenocarcinoma 610 $aPOP3 610 $apost-mitotic 610 $aprostate 610 $aregeneration 610 $asecreted protein acidic and rich in cysteine 610 $asenescence 610 $asenescence-associated secretory phenotype (SASP) 610 $asenolytics 610 $astress response 610 $atauopathy 610 $atumor infiltration 610 $a?H2AX 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aRiessland$b Markus$4edt$01327006 702 $aRiessland$b Markus$4oth 906 $aBOOK 912 $a9910557382703321 996 $aCellular Senescence in Health, Disease and Aging: Blessing or Curse$93037786 997 $aUNINA LEADER 05608nam 2201429z- 450 001 9910557690403321 005 20220111 035 $a(CKB)5400000000044627 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76628 035 $a(oapen)doab76628 035 $a(EXLCZ)995400000000044627 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCellular Metals: Fabrication, Properties and Applications 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (272 p.) 311 08$a3-0365-1038-9 311 08$a3-0365-1039-7 330 $aCellular solids and porous metals have become some of the most promising lightweight multifunctional materials due to their superior combination of advanced properties mainly derived from their base material and cellular structure. They are used in a wide range of commercial, biomedical, industrial, and military applications. In contrast to other cellular materials, cellular metals are non-flammable, recyclable, extremely tough, and chemically stable and are excellent energy absorbers. The manuscripts of this Special Issue provide a representative insight into the recent developments in this field, covering topics related to manufacturing, characterization, properties, specific challenges in transportation, and the description of structural features. For example, a presented strategy for the strengthening of Al-alloy foams is the addition of alloying elements (e.g., magnesium) into the metal bulk matrix to promote the formation of intermetallics (e.g., precipitation hardening). The incorporation of micro-sized and nano-sized reinforcement elements (e.g., carbon nanotubes and graphene oxide) into the metal bulk matrix to enhance the performance of the ductile metal is presented. New bioinspired cellular materials, such as nanocomposite foams, lattice materials, and hybrid foams and structures are also discussed (e.g., filled hollow structures, metal-polymer hybrid cellular structures). 517 $aCellular Metals 606 $aTechnology: general issues$2bicssc 610 $aA-242 alloy 610 $aacoustic characterization 610 $aage hardening 610 $aaluminium alloy foam 610 $aaluminum alloy foams 610 $aaluminum alloys 610 $aaluminum foam 610 $aaluminum matrix foam composite (AMFC) 610 $aanisotropy 610 $abeverage cans 610 $aCALPHAD 610 $acellular materials 610 $acellular metals 610 $achemical oxidation 610 $aclogging 610 $acomposites 610 $acompression test 610 $acomputational simulation 610 $acontinuous production 610 $acrystal inspiration 610 $acuckoo search algorithm 610 $adirect foaming method 610 $adrainage 610 $aelasticity 610 $aelectroless deposition nickel 610 $aenclosed gas 610 $aenergy absorption 610 $aepoxy resin 610 $aexpansion 610 $aexperimental tests 610 $aexperimental validation 610 $aexplosive compaction 610 $afabrication 610 $afinite element simulation 610 $afoam 610 $afriction welding 610 $agradient compressed porous metal 610 $agrain refinement 610 $agraphene oxide 610 $agraphene-based materials 610 $ahybrid structures 610 $ainfrared thermography 610 $alattice material 610 $aliquid fraction, X-ray diffraction 610 $amechanical 610 $amechanical characterization 610 $amechanical properties 610 $amechanics of materials 610 $amelt treatment 610 $ametal foam 610 $ametallography 610 $ametallurgy 610 $amicrostructure 610 $amodification 610 $amultiaxial yielding 610 $aMWCNT 610 $an/a 610 $ananocomposites 610 $aopen-cell aluminum foam 610 $aopen-cell foam 610 $aoptimal parameters 610 $aplasticity 610 $apolyurethane foam 610 $apore morphology 610 $aporosity 610 $aporous metal 610 $apowder metallurgy 610 $aprecipitation phase 610 $aprimary crystals 610 $arecycle 610 $arecycling 610 $asemi-solid 610 $aSIMA process 610 $aslope casting 610 $asound absorption performance 610 $atheoretical modeling 610 $athermal and acoustic properties 610 $athermal characterization 610 $atopology optimisation 610 $aunidirectional cellular structure 610 $aX-ray computed tomography 610 $aX-ray radioscopy 610 $aX-ray tomography 610 $aX-ray tomoscopy 615 7$aTechnology: general issues 700 $aDuarte$b Isabel$4edt$01322386 702 $aVesenjak$b Matej$4edt 702 $aFiedler$b Thomas$4edt 702 $aKrstulovic?-Opara$b Lovre$4edt 702 $aDuarte$b Isabel$4oth 702 $aVesenjak$b Matej$4oth 702 $aFiedler$b Thomas$4oth 702 $aKrstulovic?-Opara$b Lovre$4oth 906 $aBOOK 912 $a9910557690403321 996 $aCellular Metals: Fabrication, Properties and Applications$93034941 997 $aUNINA