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Overview of therapeutic antibodies; 2. Platform purification approaches; 3. Strategies in the context of mAb downstream process development; 4. Process-scale purification of antibody therapeutics; 5. Process analytics for mAb purification and process development; 6. Automation approaches for small-scale mAb purification and assay development; 7. Glycan characterization of therapeutics mAbs; 8. Characterization of therapeutic antibodies using mass spectrometry; 9. Antibody binding studies using surface plasmon resonance and bio-layer interferometry methods; 10. Higher-order structure characterization methods; 11. Conformational and colloidal stability analysis of mAbs; 12. Future trends and opportunities. 330 $aApproaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. 606 $aAntibody-drug conjugates 606 $aImmunoglobulins 615 0$aAntibody-drug conjugates. 615 0$aImmunoglobulins. 676 $a615.36 702 $aMattee$b Allan 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583324403321 996 $aApproaches to the purifacation, analysis and characterization of antibody-based therapeutics$93420554 997 $aUNINA LEADER 02353nam 2200541z- 450 001 9910557377303321 005 20211118 035 $a(CKB)5400000000042117 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/72940 035 $a(oapen)doab72940 035 $a(EXLCZ)995400000000042117 100 $a20202111d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeurocardiovascular Diseases: New Aspects of the Old Issues 210 $cFrontiers Media SA$d2019 215 $a1 online resource (155 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-775-3 330 $aThis eBook is a collection of articles from a Frontiers Research Topic. 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