LEADER 04699nam 2201309z- 450 001 9910557356403321 005 20231214133602.0 035 $a(CKB)5400000000042325 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76311 035 $a(EXLCZ)995400000000042325 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aUbiquitination in Health and Diseases 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (292 p.) 311 $a3-0365-0546-6 311 $a3-0365-0547-4 330 $aUbiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled ?Ubiquitination in Health and Disease? successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field. 606 $aHumanities$2bicssc 606 $aSocial interaction$2bicssc 610 $adeubiquitinase 610 $adegradation 610 $atherapeutic target 610 $acancer 610 $ahematopoiesis 610 $ahematopoietic stem cells 610 $aimmune response 610 $aregulation of gene expression 610 $aubiquitin system 610 $agenetic diseases 610 $aubiquitin ligase 610 $adeubiquitinases 610 $amonoubiquitin signaling 610 $avesicular trafficking 610 $aprotein complex formation 610 $ainflammation 610 $ainhibitor 610 $ainnate immune 610 $ainterferon 610 $aLUBAC 610 $aNF-?B 610 $aubiquitin 610 $aParkinson?s disease 610 $adopa-responsive dystonia 610 $atyrosine hydroxylase 610 $a?-synuclein 610 $afatty acid-binding protein 3 610 $aubiquitination 610 $aproteasomal degradation 610 $aubiquitin-proteasome system 610 $amitochondria 610 $aE3 ubiquitin ligase 610 $aMITOL/MARCH5 610 $asalt-sensitive hypertension 610 $aNedd4L/Nedd4-2 610 $aepithelial sodium channel 610 $aaldosterone sensitive distal nephron 610 $aexcitation-transcription coupling 610 $aRNF183 610 $aRNF186 610 $aRNF182 610 $aRNF152 610 $aRING finger 610 $amTOR 610 $aendoplasmic reticulum stress 610 $aosmotic stress 610 $aubiquitin code 610 $avirus infection 610 $avirus-host interaction 610 $atau protein 610 $asemisynthesis 610 $adisulfide-coupling 610 $apolyubiquitin 610 $afibrils 610 $aaggregation 610 $aneurodegeneration 610 $adeubiquitination 610 $ainhibitors 610 $aprotein quality control 610 $aproteolysis 610 $aprotein stabilization 610 $aregulatory T cells 610 $amesenchymal stem cell 610 $acortical bone derived stem cell 610 $amyocardial infarction 610 $ablood pressure 610 $arenal salt reabsorption 610 $avascular function 610 $aubiquitin proteasome system 610 $aubiquitin?proteasome pathway 610 $acilia 610 $aciliogenesis 610 $adifferentiation 610 $aproliferation 610 $aciliopathy 610 $aE3s 610 $aDUBs 610 $aUPS 610 $aneurodegenerative disease 610 $aimmune-related diseases 615 7$aHumanities 615 7$aSocial interaction 700 $aIshigami$b Tomoaki$4edt$01303374 702 $aIshigami$b Tomoaki$4oth 906 $aBOOK 912 $a9910557356403321 996 $aUbiquitination in Health and Diseases$93026962 997 $aUNINA