LEADER 04696nam 2201369z- 450 001 9910557354203321 005 20231214133332.0 035 $a(CKB)5400000000042348 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76822 035 $a(EXLCZ)995400000000042348 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThe Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (307 p.) 311 $a3-0365-1608-5 311 $a3-0365-1607-7 330 $aIn this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy. 606 $aMedicine$2bicssc 610 $ahypoxia 610 $amacrophages 610 $acolon cancer 610 $atumor microenvironment 610 $aimmune cell infiltration 610 $aprognosis 610 $afeline mammary carcinoma 610 $aPD-1 610 $aPD-L1 610 $aCTLA-4 610 $aTNF-? 610 $abiomarkers 610 $aimmunotherapy 610 $acancer 610 $ahistone modification 610 $ainhibitor 610 $aKDM5B 610 $amolecular docking 610 $arepurposing 610 $acancer acidity 610 $ahyperosmolarity 610 $across-presentation 610 $atumour microenvironment 610 $asyngeneic model 610 $aprostate cancer 610 $aradiotherapy 610 $apreclinical modelling 610 $amyeloid-derived suppressor cells 610 $abiomarker 610 $astroma 610 $acancer-associated fibroblast (CAF) 610 $aextracellular matrix (ECM) 610 $acytokine/chemokine 610 $agrowth factors 610 $apro- and anti-tumor immune cells 610 $aimmunomodulatory roles 610 $aradiotherapy dose fractionation 610 $aradioresistance 610 $aradiosensitivity 610 $abreast cancer 610 $aS100A10 (p11) 610 $atumor growth 610 $atumor progression 610 $ametastasis 610 $acarcinoma 610 $amammary gland 610 $atriple negative 610 $apre-metastatic niche 610 $apro-inflammatory cytokines 610 $aclinical trials 610 $aevolutionary therapy 610 $adarwinian evolution 610 $acancer cells subpopulations 610 $adiclofenac 610 $akoningic acid 610 $aspheroid 610 $a3D co-culture 610 $amicroenvironment 610 $aresistance 610 $amyeloid cells 610 $acancer development 610 $amolecular subtypes of pancreatic cancer 610 $achemotherapy response 610 $apancreatic stellate cells 610 $aregulatory T cells 610 $atumor-associated macrophages 610 $amyeloid derived suppressor cells 610 $aglioblastoma (GB) 610 $aHypoxia Inducible Factor (HIF) 610 $aglioma stem cells (GSC) 610 $aoxidative stress 610 $areactive oxygen species 610 $aplasmin 610 $aplasminogen 610 $aS100A10 610 $auPA 610 $auPAR 610 $aPAI-1 610 $aPAI-2 610 $acancer stem cells 610 $acancer recurrence 610 $atherapeutic resistance 610 $asignaling pathways 610 $atargeted therapy 610 $ahead and neck cancer 610 $alung cancer 610 $abladder cancer 615 7$aMedicine 700 $aMadureira$b Patrícia Alexandra Saraiva$4edt$01320364 702 $aMadureira$b Patrícia Alexandra Saraiva$4oth 906 $aBOOK 912 $a9910557354203321 996 $aThe Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy$93034191 997 $aUNINA